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作 者:朱荻 陈莎男 梅晓宏[1] 岳庆 常茹欣 李星[1] 刘斌[1] 张华磊 韩小龙 李媛[1] ZHU Di;CHEN Shanan;MEI Xiaohong;YUE Qing;CHANG Ruxin;LI Xing;LIU Bin;ZHANG Hualei;HAN Xiaolong;LI Yuan(Food Colloids and Nutrients Delivery Research Center,College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China;Shandong Zhongke-Jiayi Bioengineering Co.,Ltd.,Weifang 262500,China)
机构地区:[1]中国农业大学食品科学与营养工程学院,食品胶体与营养递送研究中心,北京100083 [2]山东中科嘉亿生物工程有限公司,山东潍坊262500
出 处:《食品科学》2023年第21期1-13,共13页Food Science
基 金:国家自然科学基金面上项目(32172345)。
摘 要:益生菌对人体健康发挥诸多积极作用,但由于益生菌在加工贮藏和消化过程中会发生活性损失,直接口服益生菌很难达到预期的益生效果。递送载体是一种能够提高益生菌加工贮藏稳定性、胃酸胆盐耐受性以及肠道黏附定植能力的有效方法。本综述关注益生菌口服递送的最新研究进展,总结了益生菌制剂中常用的益生菌种类及其功能特性;分析了湿度、温度、pH值、氧气等体外环境及口腔、胃、小肠等体内环境对益生菌存活率的影响;比较了微胶囊、水凝胶、油凝胶、纳米涂层、乳液、纳米纤维等不同递送载体的特点和应用情况;并对未来益生菌递送系统在降低成本、智能封装、共封装和人群实验中的应用做出展望,以期为开发贮藏稳定性高、肠道靶向递送和高活性的益生菌制剂提供技术支持。Probiotics offer numerous health benefits for human beings.However,it is difficult to achieve the expected beneficial effects of oral probiotics due to the viability loss during processing,storage and digestion.Oral delivery systems are effective ways to improve the processing and storage stability,gastric acid and bile salt tolerance,and intestinal adhesion and colonization ability of probiotics.This review focuses on the state of the art of oral delivery of probiotics,and summarizes the types of probiotics commonly used in probiotic products and their functional characteristics.Specifically,this review analyzes the effects of external environmental factors such as humidity,temperature,pH and oxygen,and internal environments such as the mouth,stomach,and small intestine on the survival rate of probiotics.Furthermore,the characteristics and applications of different oral delivery systems including microcapsule,hydrogel,oleogel,nanocoating,emulsion,and nanofiber are compared.Finally,this review proposes future prospects for cost reduction,intelligent packaging,co-packaging and population experiments of probiotic delivery systems,with the aim of providing technical support for the development of probiotic formulations with high storage stability and high viability suitable for intestinal targeted delivery.
关 键 词:益生菌 封装 递送系统 微胶囊 活菌数 肠道定植
分 类 号:TS201.3[轻工技术与工程—食品科学]
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