动物源食品中抗生素残留检测方法与研究进展  

Progress in the detection methods of antibiotic residues in animal derived food and research

作　　者：付海燕[1] 卢欢欢 龙婉君 佘远斌[2] FU Haiyan;LU Huanhuan;LONG Wanjun;SHE Yuanbin(School of Pharmaceutical Sciences,South-Central Minzu University,Wuhan 430074,China;College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]中南民族大学药学院,湖北武汉430074 [2]浙江工业大学化学工程学院,浙江杭州310014

出　　处：《轻工学报》2023年第6期37-45,共9页Journal of Light Industry

基　　金：国家自然科学基金资助项目(22208381,31972164,32122068)。

摘　　要：在简述动物源食品中抗生素常见类型、残留现状及危害的基础上,着重对动物源食品中抗生素残留检测方法与研究进展进行综述,指出:抗生素的主要类型有氟喹诺酮类、β-内酰胺类、大环内酯类、四环素类、硝基呋喃类、磺胺类、酰胺醇类和氨基糖苷类;目前抗生素滥用造成的残留问题严重,体内抗生素积累会引发过敏反应、耐药性等症状;抗生素的检测方法主要有色谱法、光谱法、电化学法、酶联免疫吸附法和化学传感法,这些方法分别存在预处理过程复杂、分析时间较长、易出现假阳性、检测种类少、难以实现多种抗生素同时检测等问题。相比而言,化学传感法在抗生素残留检测中具有过程简便快速、色变反应明显等优势,应用潜力巨大,今后可对抗生素的结构特性进行深入剖析,开发能够同时检测多种抗生素的传感器,从而进一步推动动物源食品中抗生素残留快速准确检测的发展。On the basis of a brief description of the common types of antibiotics in animal derived food,the current status of antibiotic residues and hazards,focusing on antibiotic residue detection methods and research progress in animal source foods,it was pointed out that the main types of antibiotics were fluoroquinolones,β-lactams,macrolides,tetracyclines,nitrofurans,sulfonamides,amphenicols and aminoglycosides.Currently,antibiotic abuse caused serious residual problems,and the accumulation of antibiotics in the body could trigger allergic reactions,drug resistance and other symptoms.Antibiotic detection methods mainly included chromatography,spectrometry,electrochemistry,enzyme-linked immunosorbent assay(ELISA)and chemical sensing,which respectively suffered from the problems of complicated pre-treatment process,weak anti-interference ability,susceptibility to false positives,fewer types of detection,and difficulty in realising the simultaneous detection of a variety of antibiotics,and so on.Compared with other methods,chemical sensing had the advantages of simple and rapid process,obvious color change reaction,and enormous potential for application in the detection of antibiotic residues.In the future,the structural characteristics of antibiotics can be analysed in depth,and sensors detecting a variety of antibiotics simultaneously can be developed,thus further promoting the development of rapid and accurate detection of antibiotic residues in animal derived food.

关 键 词：抗生素残留 动物源食品 食品安全 检测方法 

分 类 号：TS207.3[轻工技术与工程—食品科学]