纳米递送植物多酚防治阿尔茨海默病的研究进展  

Research Progress on Nano-Delivered Plant Polyphenols in the Prevention and Treatment of Alzheimer’s Disease

作　　者：郭慧[1] 蒋建荣[2] 梁燕子 蒋梦真 张琳[1] 周珏 钟浩 李云虹 GUO Hui;JIANG Jianrong;LIANG Yanzi;JIANG Mengzhen;ZHANG Lin;ZHOU Jue;ZHONG Hao;LI Yunhong(School of Public Health,MOE Key Laboratory of Geriatric Diseases and Immunology,Suzhou Medical College,Soochow University,Suzhou 215123,China;Suzhou Municipal Center for Disease Control and Prevention,Suzhou 215004,China;Changshu Inspection and Testing Center,Changshu Institute of Product Quality Supervision and Inspection,Changshu 215500,China;Zhejiang Key Laboratory of Efficient Development and Utilization of Deep Blue Fishery Resources,Hangzhou 310014,China)

机构地区：[1]苏州大学苏州医学院,老年病与免疫教育部重点实验室,公共卫生学院,江苏苏州215123 [2]苏州市疾病预防控制中心,江苏苏州215004 [3]常熟市检验检测中心,常熟市产品质量监督检验所,江苏常熟215500 [4]浙江省深蓝渔业资源高效开发利用重点实验室,浙江杭州310014

出　　处：《食品科学》2024年第2期315-324,共10页Food Science

基　　金：国家自然科学基金青年科学基金项目(82103818);浙江省深蓝渔业资源高效开发利用重点实验室2022年度开放基金项目(SL2022010)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是最常见的神经退行性疾病,病理机制较为复杂,随着AD发病率增加,迫切需要开发更有效的防治方法。许多研究表明植物多酚在防治神经退行性疾病方面具有巨大潜力,但是它们的生物利用度较差,在实际应用上仍存在一定的局限,利用纳米技术能够有助于植物多酚的递送。本文旨在阐述纳米递送植物多酚系统的研究进展和所面临的挑战,以及用于治疗AD的常见多酚及其作用机制。Alzheimer’s disease(AD)is one of the most common neurodegenerative diseases with a complex pathological mechanism,and as the incidence of AD has increased recently,there is an urgent need to develop more effective prevention and treatment methods.Many studies have shown that plant polyphenols have great potential in the prevention and treatment of neurodegenerative diseases,but their bioavailability is poor,limiting their practical applications.The application of nanotechnology can be helpful for the delivery of plant polyphenols.This article aims to elaborate recent progress and challenges in the development of nano-delivery systems for plant polyphenols,and review the common plant polyphenols used for AD treatment and their action mechanisms.

关 键 词：阿尔茨海默病 植物多酚 纳米递送 

分 类 号：TS201.2[轻工技术与工程—食品科学]