Emerging role of exosomes in ulcerative colitis: Targeting NOD-like receptor family pyrin domain containing 3 inflammasome  

作　　者：Xin Li Li-Jiang Ji Kai-Di Feng Hua Huang Mei-Rou Liang Shi-Jin Cheng Xiu-Dong Meng 

机构地区：[1]School of Basic Medicine,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,Guizhou Province,China [2]Department of Anorectal Surgery,Changshu Hospital Affiliated to Nanjing University of Chinese Medicine,Changshu 215500,Jiangsu Province,China [3]College of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

出　　处：《World Journal of Gastroenterology》2024年第6期527-541,共15页世界胃肠病学杂志（英文版）

基　　金：Supported by Guizhou University of Traditional Chinese Medicine Doctoral Initiation Fund,No.202306;and Changshu Municipal Science and Technology Bureau Supporting Project,No.CS202030.

摘　　要：Ulcerative colitis(UC)is a chronic recurrent inflammatory bowel disease.Despite ongoing advances in our understanding of UC,its pathogenesis is yet unelu-cidated,underscoring the urgent need for novel treatment strategies for patients with UC.Exosomes are nanoscale membrane particles that mediate intercellular communication by carrying various bioactive molecules,such as proteins,RNAs,DNA,and metabolites.The NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome is a cytosolic tripartite protein complex whose activation induces the maturation and secretion of proinflammatory cytokines interleukin-1β(IL-1β)and IL-18,triggering the inflammatory response to a pathogenic agent or injury.Growing evidence suggests that exosomes are new modulators of the NLRP3 inflammasome,with vital roles in the pathological process of UC.Here,recent evidence is reviewed on the role of exosomes and NLRP3 inflammasome in UC.First,the dual role of exosomes on NLRP3 inflammasome and the effect of NLRP3 inflammasome on exosome secretion are summarized.Finally,an outlook on the directions of exosome-NLRP3 inflammasome crosstalk research in the context of UC is proposed and areas of further research on this topic are high-lighted.

关 键 词：Ulcerative colitis EXOSOMES INFLAMMASOME Evidence THERAPEUTICS 

分 类 号：R574.62[医药卫生—消化系统]