多酚自组装抗菌生物材料的构建及其应用进展  

Construction of Polyphenol Self-assembly Antibacterial Biomaterials and Progress in Their Applications

作　　者：徐伟 俞蓉欣 张相春 张以稳 陈红平[2] 田宝明 郑芹芹 吴媛媛[3] 夏琛 韦兵 XU Wei;YU Rongxin;ZHANG Xiangchun;ZHANG Yiwen;CHEN Hongping;TIAN Baoming;ZHENG Qinqin;WU Yuanyuan;XIA Chen;WEI Bing(School of Biology and Food Engineering,Fuyang Normal University,Fuyang 236037,China;Tea Research Institute,Chinese Academy of Agricultural Sciences,Hangzhou 310008,China;Tea Research Institute,Zhejiang University,Hangzhou 310058,China;Hangzhou Yingshili Biotechnology Co.,Ltd.,Hangzhou 310000,China)

机构地区：[1]阜阳师范大学生物与食品工程学院,安徽阜阳236037 [2]中国农业科学院茶叶研究所,浙江杭州310008 [3]浙江大学茶叶研究所,浙江杭州310058 [4]杭州英仕利生物科技有限公司,浙江杭州310000

出　　处：《茶叶科学》2024年第1期1-15,共15页Journal of Tea Science

基　　金：浙江省重点研发计划(2023C02040、2022C04036);国家自然科学基金(32372757、52003053);中国农业科学院创新工程(CAAS-ASTIP-2021-TRI);国家茶叶产业技术体系(CARS-19)。

摘　　要：细菌感染可引起多种疾病,是全球主要死亡原因之一。抗生素一直是治疗细菌感染类疾病的主要策略,但抗生素的过量和不合理使用已导致多种细菌产生耐药性,严重威胁人类生命健康。植物多酚具有天然的抗菌特性,但酚羟基结构的不稳定性限制了其生物利用。为解决这个难题,研究者将多酚与其他物质自组装构建新型纳米生物材料,不仅提高了多酚稳定性和生物利用率,还使其协同发挥抗菌活性,在抗菌领域中具有巨大的应用潜力和优势。综述了近年来不同类型的多酚自组装生物纳米材料构建策略及抗菌性能,包括多酚-金属、多酚-水凝胶、多酚-壳聚糖、多酚-蛋白质和多酚-脂质体等材料,指出了新型多酚自组装生物材料在抗菌领域应用中面临的问题,并对其应用前景进行了展望。Bacterial infection,a leading cause of global mortality,can result in various diseases.While antibiotics are the primary treatment for infections,their excessive and irrational use has led to the emergence of a variety of bacterial drug resistance,posing a serious threat to human health.Plant polyphenols have natural antibacterial properties,but the instability of the phenolic hydroxyl structure limits their bioavailability.To solve this problem,researchers have explored the self-assembly of polyphenols with other substances to construct new nano-biomaterials.These biomaterials not only enhance the stability and bioavailability of polyphenols but also exhibit synergistic antibacterial activity,showing a great promise in the field of antibacterial applications.This review examined the construction strategies and antibacterial properties of different types of polyphenol self-assembled biomaterials developed in recent years,including polyphenol-metal,polyphenol-hydrogel,polyphenol-chitosan,polyphenol-protein and polyphenol-liposome.Furthermore,the challenges and future prospects of the novel polyphenol self-assembling biomaterials in the field of antibacterial application were discussed.

关 键 词：多酚 自组装 纳米材料 抗菌应用 

分 类 号：S571.1[农业科学—茶叶生产加工] R318.08[农业科学—作物学]