基于孟德尔随机化的DHA水平与ADHD的关系研究  

Study on relationship between docosahexaenoic acid level and attention deficithyperactivity disorder based on Mendelian randomization

作　　者：张郑 谭景蓝 罗庆华[1] ZHANG Zheng;TAN Jinglan;LUO Qinghua(Department of Psychiatry,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院精神科,重庆400016

出　　处：《重庆医学》2024年第8期1151-1156,共6页Chongqing medicine

基　　金：重庆市科卫联合医学科研项目(2020GDRC026)。

摘　　要：目的基于孟德尔随机化(MR)探讨二十二碳六烯酸(DHA)水平与注意缺陷与多动障碍(ADHD)发病的关系。方法从已发表的全基因组关联研究数据(GWAS)中提取了DHA和ADHD的工具变量,为了确保研究结果的稳定性,ADHD数据集选自两个不同的研究。DHA水平的数据集包括115006例个体,ADHD1数据集共55374例个体涵盖20183例病例和35191例对照,ADHD2共225534例个体涵盖38691例病例和186843例对照,进行全面MR分析和敏感性分析。应用逆方差加权法(IVW)、MR-Egger回归分析及加权中位数法(WM)进行MR分析,以优势比(OR)和回归系数(β)作为评价指标,对DHA与ADHD的双向因果关系进行探讨。结果DHA与ADHD发病存在因果关系(ADHD1的IVW:OR=0.833,95%CI:0.719~0.964,P=0.014;ADHD2的IVW:OR=0.895,95%CI:0.808~0.992,P=0.034)。此外,发现ADHD与DHA存在反向因果关系(IVW:β=-0.073,95%CI:-0.103~-0.043,P<0.001)。结论DHA水平与ADHD存在潜在的双向因果关系。Objective To investigate the relationship between docosahexaenoic acid(DHA)level and the onset of attention deficit hyperactivity disorder(ADHD)based on Mendelian Randomization(MR).Methods The instrumental variables for DHA and ADHD were extracted from the genome-wide association studies(GWAS)data.To ensure the stablity of the study results,the ADHD datasets were selected from two different studies.The The dataset for DHA levels included 115,006 individuals,the ADHD1 dataset consisted of 55374 individuals,including 20183 cases and 35191 controls,the ADHD2 dataset consisted of 225534 individuals,including 38691 cases and 186843 controls,the comprehensive MR and sensitivity analyses were performed.The MR analyses were performed by the inverse variance weighted(IVW)method,MR-Egger regression analysis and the weighted median method(WM),utilizing the odds ratio(OR)and effect coefficient(β)as evaluation indictors to explore the bidirectional causal relationship between DHA and ADHD.Results There exists a causal link between DHA levels and the onset of ADHD(ADHD1 IVW:OR=0.833,95%CI:0.719-0.964,P=0.014;ADHD2 IVW:OR=0.895,95%CI:0.808-0.992,P=0.034).Additionally,a reverse causal relationship between ADHD and DHA levels(IVW:β=-0.073,95%CI:-0.103 to-0.043,P<0.001)was found.Conclusion The potential bidirectional causal relationship exists between DHA level and ADHD.

关 键 词：二十二碳六烯酸 注意缺陷与多动障碍 孟德尔随机化 因果推断 儿童心理 

分 类 号：R749.94[医药卫生—神经病学与精神病学]