虾青素口服纳米制剂的研究进展  

Research Progress on Oral Nano-formulation to Deliver Astaxanthin

作　　者：仲晨 刘梅 高焱 徐科凤 王颖 ZHONG Chen;LIU Mei;GAO Yan;XU Kefeng;WANG Ying(Marine Science Research Institute of Shandong Province,Qingdao 266104,China;Municipal Engineering Research Center of Aquatic Biological Quality Evaluation and Application,Qingdao 266104,China)

机构地区：[1]山东省海洋科学研究院,山东青岛266104 [2]青岛市水产生物品质评价工程研究中心,山东青岛266104

出　　处：《食品工业科技》2024年第10期395-400,共6页Science and Technology of Food Industry

基　　金：山东省现代农业虾蟹产业技术体系建设任务-加工与质量控制岗位(SDAIT-13-07);山东省海洋科学研究院科研补助经费项目-集约化养殖渔用生物制品开发与应用。

摘　　要：虾青素(Astaxanthin,AST)是一种脂溶性叶黄素类胡萝卜素,具有良好的抗氧化、抗炎和免疫调节活性。然而,因其口服生物利用度较差,临床应用有限。近年来,为了提高虾青素的生物利用度,各种类型的纳米制剂被广泛研究。其中纳米乳液、脂质体、固体脂质纳米颗粒、壳聚糖纳米颗粒和聚乳酸-羟基乙酸聚合物(poly(lactic-co-glycolic acid),PLGA)纳米颗粒已被证明可有效提高虾青素的口服生物利用度。本综述中,基于体外和体内研究数据和结果,总结了不同类型的纳米制剂对于提高虾青素口服生物利用度的研究进展,为今后虾青素口服剂型的开发提供参考,实现其在临床中的应用价值。Astaxanthin is a fat-soluble lutein carotenoid with good antioxidant,anti-inflammatory and immunomodulatory activities.However,its poor oral bioavailability lead to limited clinical application.Recently,in order to improve the bioavailability of astaxanthin,various types of nano-formulations have been widely studied.Nano-emulsion,liposome,solid lipid nanoparticles,chitosan and PLGA nanoparticles have been shown to effectively improve the oral bioavailability of astaxanthin.In this review,based on in vitro and in vivo studies,the research progress of nano-formulations for improving the oral bioavailability of astaxanthin are summarized,providing reference for the development of oral delivery of astaxanthin,and achieving its clinical application value in the future.

关 键 词：虾青素 口服制剂 纳米颗粒 生物利用度 

分 类 号：TS201.1[轻工技术与工程—食品科学]