Interleukin-1β:Friend or foe for gastrointestinal cancers  

作　　者：Kullanat Khawkhiaw Jutatip Panaampon Thanit Imemkamon Charupong Saengboonmee 

机构地区：[1]Department of Biochemistry,Faculty of Medicine,Khon Kaen University,Khon Kaen 40002,Thailand [2]Center for Translational Medicine,Faculty of Medicine,Khon Kaen University,Khon Kaen 40002,Thailand [3]Cholangiocarcinoma Research Institute,Khon Kaen University,Khon Kaen 40002,Thailand [4]Department of Medical Oncology,Dana-Farber Cancer Institute,Harvard Medical School,Boston,MA 02215,United States [5]Department of Medicine,Harvard Medical School,Boston,MA 02215,United States [6]Division of Hematopoiesis,Joint Research Center for Human Retrovirus Infection,Kumamoto University,Kumamoto 860-0811,Japan [7]Department of Medicine,Faculty of Medicine,Khon Kaen Univsersity,Khon Kaen 40002,Thailand

出　　处：《World Journal of Gastrointestinal Oncology》2024年第5期1676-1682,共7页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：Supported by National Research Council of Thailand,No.N41A640108;Mekong-Lancang Cooperation Special Fund;The Development and Promotion of Science and Technology Talents Project;Ministry of Education,Science,Sports,and Culture of Japan,No.22K16327 and No.22K08482.

摘　　要：Gastrointestinal(GI)cancer is a malignancy arising in the digestive system and accounts for approximately a third of increasing global cancer-related mortality,especially in the colorectum,esophagus,stomach,and liver.Interleukin-1β(IL-1β)is a leukocytic pyrogen recognized as a tumor progression-related cytokine.IL-1βsecretion and maturation in inflammatory responses could be regulated by nuclear factor-kappaB-dependent expression of NLR family pyrin domain containing 3,inflammasome formation,and activation of IL-1 converting enzyme.Several studies have documented the pro-tumorigenic effects of IL-1β in tumor microenvironments,promoting proliferation and metastatic potential of cancer cells in vitro and tumorigenesis in vivo.The application of IL-1β inhibitors is also promising for targeted therapy development in some cancer types.However,as a leukocytic pro-inflammatory cytokine,IL-1β may also possess anti-tumorigenic effects and be type-specific in different cancers.This editorial discusses the up-to-date roles of IL-1β in GI cancers,including underlying mechanisms and down-stream signaling pathways.Understanding and clarifying the roles of IL-1β would significantly benefit future therapeutic targeting and help improve therapeutic outcomes in patients suffering from GI cancer.

关 键 词：CANCER Gastrointestinal tract INFLAMMATION INTERLEUKIN-1Β Tumor microenvironment 

分 类 号：R735[医药卫生—肿瘤]