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作 者:Zuen Ren Bryce Ordway Po-Han Lin
机构地区:[1]Cancer Center,Massachusetts General Hospital,Boston,MA,USA [2]Department of Medicine,Harvard Medical School,Boston,MA 02114,USA [3]Broad Institute of Harvard and Massachusetts Institute of Technology,Cambridge,MA 02142,USA
出 处:《The Innovation》2024年第1期3-4,共2页创新(英文)
摘 要:In a recent issue of Cell,Kaile and colleagues reported a robust highthroughput single-cell DNA sequencing(scDNA-seq)technique,named ArcWell,that enables the researchers to overcome huge challenges while studying cancer genomic evolution in formalin-fixed and paraffin-embedded(FFPE)samples from clinical cancer patients.By the application of this technique,the team revealed a clearer view of the clonal diversity of breast ductal carcinoma in situ(DCIS)and genomic evolution of DCIS to recurrent disease.
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