Alpha-synuclein in mitochondrial dysfunction:opportunities or obstacles  

作　　者：Shermali Gunawardena 

机构地区：[1]Department of Biological Sciences,The State University of New York at Buffalo,Buffalo,NY,USA

出　　处：《Neural Regeneration Research》2025年第1期197-198,共2页中国神经再生研究（英文版）

摘　　要：Recent work suggests a link betweenα-synuclein(α-syn)and mitochondrial dysfunction;however,the mechanisms of howα-syn influences mitochondrial function are still unclear.Most notably,whetherα-syn plays a direct role during mitochondrial function and/or whether diseasedα-syn-mediated mitochondrial dysfunction is a potential modifiable risk factor in Parkinson’s disease(PD)is unknown.To date,mutations in more than eight genes cause familial PD(fPD)and have functions in diverse pathways including synaptic homeostasis,mitochondria maintenance,autophagy/lysosome,and ubiquitin-proteasome pathways.

关 键 词：DYSFUNCTION HOMEOSTASIS ALPHA 

分 类 号：R741[医药卫生—神经病学与精神病学]