绿原酸衍生物的制备及其活性研究进展  

Research Advances in the Preparation and Bioactivity of Chlorogenic Acid Derivatives

作　　者：宋帅涛 张逸[1] 张羽飞 钟华英 金静 郑明明[1,2] Song Shuaitao;Zhang Yi;Zhang Yufei;Zhong Huaying;Jin Jing;Zheng Mingming(Oil Crops Research Institute of Chinese Academy of Agricultural Sciences,Hubei Hongshan Lab,Hubei Key Laboratory of Lipid Chemistry and Nutrition,Key Laboratory of Oilseeds Processing,Ministry of Agriculture and Rural Affairs,Wuhan 430062;Huzhou City Linghu Xinwang Chemical Co.Ltd.,Huzhou 313018,Zhejiang)

机构地区：[1]中国农业科学院油料作物研究所湖北洪山实验室油料脂质化学与营养湖北省重点实验室农业农村部油料加工重点实验室,武汉430062 [2]湖州市菱湖新望化学有限公司,浙江湖州313018

出　　处：《中国食品学报》2024年第4期469-479,共11页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家自然科学基金青年科学基金项目(32302021);国家重点研发计划项目(2021YFD2100303);湖北省自然科学基金项目(2023AFB324);中央公益类科研机构基础研究基金(1610172022014);湖州市南太湖精英计划领军型创新团队项目。

摘　　要：绿原酸是一种具有生物活性的水溶性酚类衍生物,然而其低脂溶特性限制了它的产业应用。通过分子修饰制备的绿原酸衍生物,能够显著提升其脂溶性且保留绿原酸本体的生物活性。本文综述以酰氯法为代表的化学法以及酯化法、酯交换法等酶法制备绿原酸衍生物的研究进展,讨论绿原酸衍生物常用的分离和纯化手段,并探讨近年来绿原酸衍生物的抗氧化、抗肿瘤、抗真菌和调节脂质代谢等生物活性的相关研究,总结现阶段绿原酸衍生物研究中存在的问题,并展望未来发展趋势和应用。Chlorogenic acid(CGA)is a type of water-soluble phenolic derivatives with a variety of physiological functions,but its low lipid solubility limit CGA's industrial applicability.Molecular modification is an effective approach to synthesize chlorogenic acid derivatives(CAD)which have higher liposolubility and comparable bioactivities to CGA.In this paper,the preparation of CAD using chemical methods including the acyl chloride method and enzymatic methods,such as esterification and ester exchange are reviewed.The typical approaches for the isolation and purification of CAD are discussed.Besides,the recent advances in chlorogenic acid derivatives'bioactivities including the antioxidant,antitumor and antifungal functions,lipid metabolism regulation properties are evaluated.Finally,the current issues in CAD study and potential applicability in future are summarized.

关 键 词：绿原酸衍生物 化学法 酶法制备 抗氧化 生物活性 

分 类 号：TS201.2[轻工技术与工程—食品科学]