Systematic pan-cancer analysis reveals OGT and OGA as potential biomarkers for tumor microenvironment and therapeutic responses  

作　　者：Chunyan Hou Ci Wu Wenge Zhu Huadong Pei Junfeng Ma 

机构地区：[1]Department of Oncology,Lombardi Comprehensive Cancer Center,Georgetown University,Washington,DC 20007,USA [2]Department of Biochemistry and Molecular Medicine,School of Medicine and Health Science,George Washington University,Washington,DC20052,USA

出　　处：《Genes & Diseases》2024年第4期1-4,共4页基因与疾病（英文）

基　　金：supported by the National Institutes of Health(NIH)/the National Cancer Institute(NCI)(No.P30 CA051008).

摘　　要：Protein O-linkedβ-N-acetylglucosamine(O-GlcNAc)modification(O-GlcNAcylation)is a unique monosaccharide modification of essential importance in physiology and pathology.1,2 As a highly dynamic process,O-GlcNAcylation is mediated by two paired enzymes:O-GlcNAc transferase(OGT)and O-GlcNAcase(OGA),which add or remove the modification from proteins,respectively.Emerging evidence demonstrates that the aberrant O-GlcNAcylation underlies the initiation,progression,and metastasis of cancer.

关 键 词：METASTASIS PATHOLOGY THERAPEUTIC 

分 类 号：R730.5[医药卫生—肿瘤]