决明子的药理学作用及其在食品领域应用研究进展  

Research Progress on the Pharmacological Effects and Applications in the Field of Food of Cassiae Semen

作　　者：毛琳 余黎 许增智 王靖仪 郭鹏 刘明扬 孙宗宇 史雪盟 许君[1] MAO Lin;YU Li;XU Zengzhi;WANG Jingyi;GUO Peng;LIU Mingyang;SUN Zongyu;SHI Xuemeng;XU Jun(College of Life Sciences,Henan Agricultural University,Zhengzhou 450002,China)

机构地区：[1]河南农业大学生命科学学院,河南郑州450002

出　　处：《食品工业科技》2024年第16期425-438,共14页Science and Technology of Food Industry

基　　金：国家自然科学基金项目(U1804108);国家自然科学基金青年科学基金(32300140);河南省自然科学基金面上项目(232300421157);河南省自然科学基金青年项目(242300421574);中国博士后科学基金面上资助项目(2022M711060);河南农业大学高层次人才专项支持基金(30501346)。

摘　　要：决明子是豆科植物决明(Cassia obtusifolia Linn.)或小决明(Cassia.tora Linn.)的干燥成熟的种子,具有清热明目、润肠通便、降压降脂、保肝护肝、抗糖尿病等多种药理学功效,且其具有药食同源的特性,在医学与食品领域具有广阔的开发前景。本文通过对现有的文献进行归纳和分析,从决明子的生物活性成分、药理学作用、毒性及其在食品领域的应用等方面对决明子近年来的研究进展进行了系统的综述。同时,讨论了目前决明子研究中出现的新挑战和可能的发展方向。在决明子未来的研究中,应进一步关注萘并吡酮类和多糖类的药理作用及其改善眼病的作用机制,重点加强决明子的药代动力学研究和相关保健食品的安全性评价。本文为决明子的进一步研究、开发和利用提供新的基础资料。Cassia Semen,derived from the dried ripe seeds of leguminous plant Cassia obtusifolia Linn.or Cassia.tora Linn.,exhibits a variety of pharmacological effects such as clearing heat to brighten the eyes,lubricating the intestine to relieve constipation,lowering blood pressure and lipids,hepatoprotection and anti-diabetes,etc.And due to its homology of medicine and food,it has broad development prospects in the fields of medicine and food.Based on the summary and analysis of the published literatures,this paper systematically reviews the integrated research progress of Cassiae Semen in recent years from the aspects of bioactive ingredients,pharmacological effects,toxicity and its applications in the food field.Additionally,the emerging challenges and possible development directions for the study of Cassiae Semen are discussed as well.In future research on Cassiae Semen,more attention should be paid to the pharmacological effects of naphthopyranones and polysaccharides and their mechanisms underlying improving eye diseases.Meanwhile,it is essential to focus on strengthening the researches on the pharmacokinetics of Cassiae Semen and the safety evaluation of its related functional foods.This article provides new basic information for further research,development,and utilization of Cassiae Semen.

关 键 词：决明子 生物活性成分 药理学作用 毒性 食品领域 

分 类 号：TS201.2[轻工技术与工程—食品科学]