PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype  

作　　者：Fengsheng Dai Yixiao Yuan Jiaqi Hao Xing Cheng Xiangyi Zhou Li Zhou Rui Tian Yi Zhao Tingxiu Xiang 

机构地区：[1]Department of Oncology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China [2]Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Chongqing University Cancer Hospital,Chongqing 400030,China [3]Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [4]Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [5]Department of Neuro-Oncology,Chongqing University Cancer Hospital,Chongqing 400030,China

出　　处：《Genes & Diseases》2024年第5期390-406,共17页基因与疾病（英文）

基　　金：the National Natural Science Foundation of China(No.82172619);the Natural Science Foundation of Chongqing,China(No.CSTC2021jscx-gksbN0023);the Fundamental Research Funds for the Central Universities in China(No.2022CDJYGRH-002).

摘　　要：Programmed cell death 2(PDCD2)is related to cancer progression and chemotherapy sensitivity.The role of PDCD2 in solid cancers(excluding hematopoietic malignancies)and their diagnosis and prognosis remains unclear.The TCGA,CGGA,GEPIA,cBioPortal,and GTEx databases were analyzed for expression,prognostic value,and genetic modifications of PDCD2 in cancer patients.Functional enrichment analysis,CCK8,colony formation assay,transwell assay,and xenograft tumor model were undertaken to study the PDCD2’s biological function in glioma(GBMLGG).The PDCD2 gene was associated with solid cancer progression.In the functional enrichment analysis results,PDCD2 was shown to participate in several important GBMLGG biological processes.GBMLGG cells may be inhibited in their proliferation,migration,invasion,and xenograft tumor growth by knocking down PDCD2.Our research can provide new insights into solid cancer prognostic biomarkers of PDCD2.

关 键 词：BIOMARKER GLIOMA Programmed cell death 2 PROGRESSION Solid cancer 

分 类 号：R739.41[医药卫生—肿瘤]