Role of dopamine in the pathophysiology of Parkinson’s disease  

作　　者：Zhi Dong Zhou Ling Xiao Yi Dennis Qing Wang Tit Meng Lim Eng King Tan 

机构地区：[1]National Neuroscience Institute of Singapore,11 Jalan Tan Tock Seng,Singapore 308433,Singapore [2]Department of Neurology,Singapore General Hospital,Outram Road,Singapore 169608,Singapore [3]Signature Research Program in Neuroscience and Behavioral Disorders,Duke-NUS Graduate Medical School Singapore,8 College Road,Singapore 169857,Singapore [4]Department of Neurology,Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China [5]Department of Biological Science,National University of Singapore,Singapore 119077,Singapore

出　　处：《Translational Neurodegeneration》2023年第1期281-295,共15页转化神经变性病（英文）

基　　金：supported by grants from the Singapore National Medical Research Council(CS-IRG,HLCA2022,STaR,OF LCG 000207);a clinical translational research programme in Parkinson’s disease and a Duke-Duke-NUS collaboration pilot grant.

摘　　要：A pathological feature of Parkinson’s disease(PD)is the progressive loss of dopaminergic neurons and decreased dopamine(DA)content in the substantia nigra pars compacta in PD brains.DA is the neurotransmitter of dopaminergic neurons.Accumulating evidence suggests that DA interacts with environmental and genetic factors to contribute to PD pathophysiology.Disturbances of DA synthesis,storage,transportation and metabolism have been shown to promote neurodegeneration of dopaminergic neurons in various PD models.DA is unstable and can undergo oxidation and metabolism to produce multiple reactive and toxic by-products,including reactive oxygen species,DA quinones,and 3,4-dihydroxyphenylacetaldehyde.Here we summarize and highlight recent discoveries on DA-linked pathophysiologic pathways,and discuss the potential protective and therapeutic strategies to mitigate the complications associated with DA.

关 键 词：DOPAMINE Dopamine quinones 3 4-Dihydroxyphenylacetaldehyde NEURODEGENERATION PATHOGENESIS Parkinson’s disease Reactive oxygen species Therapeutic strategies 

分 类 号：R742.5[医药卫生—神经病学与精神病学]