Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout:Insights and therapeutic strategies  

作　　者：Abhay Kumar Singh Siva Sundara Kumar Durairajan Ashok Iyaswamy Leonard L Williams 

机构地区：[1]Department of Microbiology,School of Life Sciences,Central University of Tamil Nadu,Tiruvarur,TN 610005,India [2]School of Biomedical Sciences,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong 999077,China [3]School of Chinese Medicine,Hong Kong Baptist University,Hong Kong 999077,China [4]Department of Biochemistry,Karpagam Academy of Higher Education,Coimbatore 641021,India [5]Center for Excellence in Post-Harvest Technologies,North Carolina Agricultural and Technical State University,Greensboro,NC 27411,United States

出　　处：《World Journal of Gastroenterology》2024年第40期4404-4410,共7页世界胃肠病学杂志（英文）

摘　　要：Hyperuricemia(HUA)is a condition associated with a high concentration of uric acid(UA)in the bloodstream and can cause gout and chronic kidney disease.The gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy people.This article focused on the complex interconnection between alterations in the gut microbiota and the development of this disorder.Some studies have suggested that changes in the composition,diversity,and activity of microbes play a key role in establishing and progressing HUA and gout pathogenesis.Therefore,we discussed how the gut microbiota contributes to HUA through purine metabolism,UA excretion,and intestinal inflammatory responses.We examined specific changes in the composition of the gut microbiota associated with gout and HUA,highlighting key bacterial taxa and the metabolic pathways involved.Additionally,we discussed the effect of conventional gout treatments on the gut microbiota composition,along with emerging therapeutic approaches that target the gut microbiome,such as the use of probiotics and prebiotics.We also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis.

关 键 词：Gut microbiota DYSBIOSIS GOUT HYPERURICEMIA Inflammation Intestinal barrier PROBIOTICS PREBIOTICS Fecal microbiota transplantation 

分 类 号：R575.3[医药卫生—消化系统]