Novel perspectives on leptin in osteoarthritis:Focus on aging  

作　　者：Zimo Liu Wenqing Xie Hengzhen Li Xu Liu Yao Lu Bangbao Lu Zhenhan Deng Yusheng Li 

机构地区：[1]Department of Orthopedics,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [2]Department of Orthopaedic Surgery,The First Affliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China [3]Xiangya School of Medicine,Central South University,Changsha,Hunan 410083,China [4]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China

出　　处：《Genes & Diseases》2024年第6期237-257,共21页基因与疾病（英文）

基　　金：supported by the National Key R&D Program of China (No.2019YFA0111900);the National Natural Science Foundation of China (No.81874030,82072506);the National Clinical Research Center for Geriatric Disorders (China) (No.2021LNJJ05);the Provincial Key R&D Program of Hunan,China (No.2020SK2075);the Administration of Traditional Chinese Medicine of Hunan Province,China (No.2021075);the Innovation-Driven Project of Central South University (China) (No.2020CX045);Hunan Yong Talents of Science and Technology (China) (No.2021RC3025);Wu Jieping Medical Foundation (No.320.6750.2020-03-14);the Independent Exploration,Innovation Project for Postgraduate Students of Central South University (China) (No.2021zzts1024);the Hunan Provincial Innovation Foundation for Postgraduate (China) (No.CX20210360);Guangdong Basic and Applied Basic Research Foundation (China) (No.2021A1515220030).

摘　　要：t Osteoarthritis(OA)is a common chronic joint disease characterized by articular cartilage degeneration,subchondral sclerosis,synovitis,and osteophyte formation.OA is asso-ciated with disability and impaired quality of life,particularly among the elderly.Leptin,a 16-kD non-glycosylated protein encoded by the obese gene,is produced on a systemic and local basis in adipose tissue and the infrapatellar fat pad located in the knee.The metabolic mech-anisms employed by leptin in OA development have been widely studied,with attention being paid to aging as a corroborative risk factor for OA.Hence,in this review,we have attempted to establish a potential link between leptin and OA,by focusing on aging-associated mechanisms and proposing leptin as a potential diagnostic and therapeutic target in aging-related mecha-nisms of OA that may provide fruitful guidance and emphasis for future research.

关 键 词：AGING Articular chondrocytes Cellular senescence DEGENERATION LEPTIN OSTEOARTHRITIS 

分 类 号：R684.3[医药卫生—骨科学]