Wnt/β-catenin signaling components and mechanisms in bone formation,homeostasis,and disease  

作　　者：Lifang Hu Wei Chen Airong Qian Yi-Ping Li 

机构地区：[1]Laboratory for Bone Metabolism,Xi’an Key Laboratory of Special Medicine and Health Engineering,Key Laboratory for Space Biosciences and Biotechnology,Research Center for Special Medicine and Health Systems Engineering,School of Life Sciences,Northwestern Polytechnical University,Xi’an,Shaanxi,710072,China [2]Division in Cellular and Molecular Medicine,Department of Pathology and Laboratory Medicine,Tulane University School of Medicine,Tulane University,New Orleans,LA,70112,USA

出　　处：《Bone Research》2024年第3期469-501,共33页骨研究（英文版）

基　　金：supported by the National Natural Science Foundation of China (81772017 to[L.F.H.],and 82072106 and 32371371 to[A.R.Q.]);The Project Supported by Natural Science Basic Research Plan in Shaanxi Province of China (2023-JC-YB-163 to[L.F.H.]);the National Institutes of Health[AR-070135 and AG-056438 to W.C.,and AR075735,DE023813,AR074954,and DE028264 to Y.P.L.]。

摘　　要：Wnts are secreted,lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways,which control various biological processes throughout embryonic development and adult life.Aberrant Wnt signaling pathway underlies a wide range of human disease pathogeneses.

关 键 词：HOMEOSTASIS CANONICAL MECHANISMS 

分 类 号：R363[医药卫生—病理学]