Neutrophil extracellular traps in homeostasis and disease  

作　　者：Han Wang Susan JKim Yu Lei Shuhui Wang Hui Wang Hai Huang Hongji Zhang Allan Tsung 

机构地区：[1]Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China [2]Department of Surgery,School of Medicine,University of Virginia,Charlottesville,VA,USA [3]Department of Medical Genetics,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China [4]Feinstein Institutes for Medical Research,Manhasset,NY,USA

出　　处：《Signal Transduction and Targeted Therapy》2024年第10期4408-4447,共40页信号转导与靶向治疗（英文）

基　　金：National Institute of Health grants R01-CA214865 to A.T.State funding within the UVA Comprehensive Cancer Center“IDEA-Cancer pilot award”,“Cancer Therapeutics(CRX)pilot award”to H.Z.National Natural Science Foundation of China Grant Number 82200588 to H.W.

摘　　要：Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and disease pathogenesis, has grown significantly in recent years. NETs are not only pivotal in the context of infections but also exhibit significant involvement in sterile inflammation. Evidence suggests that excessive accumulation of NETs can result in vessel occlusion, tissue damage, and prolonged inflammatory responses, thereby contributing to the progression and exacerbation of various pathological states. Nevertheless, NETs exhibit dual functionalities in certain pathological contexts. While NETs may act as autoantigens, aggregated NET complexes can function as inflammatory mediators by degrading proinflammatory cytokines and chemokines. The delineation of molecules and signaling pathways governing NET formation aids in refining our appreciation of NETs’ role in immune homeostasis, inflammation, autoimmune diseases, metabolic dysregulation, and cancer. In this comprehensive review, we delve into the multifaceted roles of NETs in both homeostasis and disease, whilst discussing their potential as therapeutic targets. Our aim is to enhance the understanding of the intricate functions of NETs across the spectrum from physiology to pathology.

关 键 词：HOMEOSTASIS INVOLVEMENT INFLAMMATION 

分 类 号：R57[医药卫生—消化系统]