乳酸菌基因组规模代谢建模研究与在食品体系中的应用进展  

Research Progress on Genome-Scale Metabolic Models of Lactic Acid Bacteria and Their Application in the Food System

作　　者：刘子豪 倪皓洁 李文璐 王凤忠[2] 王彦波 曾黉 LIU Zihao;NI Haojie;LI Wenlu;WANG Fengzhong;WANG Yanbo;ZENG Hong(School of Food and Health,Beijing Technology and Business University,Beijing 100048,China;Key Laboratory of Agro-products Quality&Safety in Harvest,Storage,Transportation,Management and Control,Ministry of Agriculture and Rural Affairs,Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Beijing 100193,China)

机构地区：[1]北京工商大学食品与健康学院,北京100048 [2]中国农业科学院农产品加工研究所,农业农村部农产品质量安全收贮运管控重点实验室,北京100193

出　　处：《食品科学》2024年第24期348-356,共9页Food Science

基　　金：农业农村部农产品质量安全收贮运管控重点实验室开放课题项目(S2023KFKT-06)。

摘　　要：乳酸菌具有改善食品风味、提高营养价值等重要作用,被广泛应用于食品发酵领域。基因组规模代谢模型是研究微生物代谢的重要工具,可以模拟生物体内代谢网络、准确描述基因型-表型关系,目前已成功应用于乳酸菌代谢调控等研究中。本文系统回顾了近20年以来构建的乳酸菌基因组规模代谢模型,并重点综述了现有模型在食品体系中的应用情况。本文在分析现有模型存在的主要挑战与局限性的同时,结合目前新技术、新思想对其未来发展方向进行展望,旨在为未来如何更加有效、准确地将乳酸菌基因组规模代谢模型有机地应用在食品工业,辅助食品微生物群落智慧设计提供参考。Lactic acid bacteria(LAB)play a crucial role in improving the flavor and enhancing the nutritional value food,which have found wide application in the field of food fermentation.Genome-scale metabolic models(GSMMs)serve as essential tools for studying microbial metabolism,which simulate the metabolic networks of microorganisms and accurately describe the genotype-phenotype relationships.Several GSMMs have already been successfully applied to the metabolic regulation of LAB.This article systematically summarizes LAB GSMMs constructed over the past two decades,emphasizing their application in food systems.Moreover,it analyzes the primary challenges and limitations of the GSMMs and gives an outlook on future directions in by combining emerging technologies and innovative ideas.The final goal is to provide valuable insights for the effective and precise application of LAB GSMMs to the intelligent design of microbial communities in the food industry.

关 键 词：乳酸菌 基因组规模代谢模型 代谢模拟 食品工业 

分 类 号：TS201.3[轻工技术与工程—食品科学]