红曲霉菌降血脂功能活性及应用研究进展  

Research Progress in the Blood Lipid-Lowering Activity and Application Status of Monascus

作　　者：阿卜力米提·阿尔祖古丽 王海蛟 王聪聪[1] 孙晴 董慧君 张婵[1,2] 王蓓 王成涛[1,2] ABLIMIT Arzugul;WANG Haijiao;WANG Congcong;SUN Qing;DONG Huijun;ZHANG Chan;WANG Bei;WANG Chengtao(School of Food and Health,Beijing Technology and Business University,Beijing 100048,China;Beijing Engineering and Technology Research Center of Food Additives,Beijing 100048,China)

机构地区：[1]北京工商大学食品与健康学院,北京100048 [2]北京市食品添加剂工程技术研究中心,北京100048

出　　处：《食品与生物技术学报》2024年第11期11-22,共12页Journal of Food Science and Biotechnology

基　　金：国家自然科学基金面上项目(32172185,32072345)。

摘　　要：近年来心脑血管疾病发病率显著上升,已经成为全球公共卫生的重大挑战,严重威胁了人类健康。红曲霉菌(Monascus)能够通过代谢过程产生他汀类、红曲色素、γ-氨基丁酸等多种生物活性成分,这些成分可以降低血脂、血压、血糖,同时也可预防或治疗肿瘤、炎症、骨质疏松等疾病。因此,红曲霉菌在医疗、食品增补剂、酿造食品、生物催化等多个领域得到广泛应用,且基于红曲霉菌研发的降脂制剂正逐渐成为人们的新选择。作者对红曲霉菌及其代谢产物的降血脂作用以及用红曲霉菌制作的降血脂补充剂的应用现状进行了综述,为红曲霉菌相关功能性食品的研发和应用提供参考。Cardiovascular and cerebrovascular diseases with increasing incidence rates in recent decades have become a great challenge to public health on a global scale,posing a threat to human health.Monascus can produce various bioactive components such as statins,Monascus pigment,andγ-aminobutyric acid through metabolic processes.These components can help decrease the levels of blood lipid,blood pressure,and blood glucose while preventing and treating diseases such as tumors,inflammation,and osteoporosis.Therefore,Monascus has been widely used in multiple fields such as medical treatment,food supplements,brewing foods,and biocatalysis.Especially,blood lipid-lowering preparations based on Monascus are gradually becoming a new choice for people's health management.The author provides an overview of the blood lipid-lowering effects of Monascus and its metabolites,as well as the current application status of blood lipid-lowering supplements produced from Monascus,providing reference for the research and application of functional foods related to Monascus.

关 键 词：红曲霉菌 Monacolin K 红曲色素 降血脂 制剂 

分 类 号：TS2[轻工技术与工程—食品科学与工程]