The microglial P2Y_(6) receptor as a therapeutic target for neurodegenerative diseases  

作　　者：Jacob M.Dundee Guy C.Brown 

机构地区：[1]Department of Biochemistry,University of Cambridge,Cambridge,UK

出　　处：《Translational Neurodegeneration》2024年第1期377-387,共11页转化神经变性病(英文)

基　　金：funded by the Medical Research Council UK(MR/L010593);Alzheimer’s Research UK(Dementia Consortium Grant ARUK-DC2017-4,Network Grant G-102212);the Wellcome Trust(Wellcome Institutional Partnership Award 222062/Z/20/Z).

摘　　要：Neurodegenerative diseases are associated with chronic neuroinflammation in the brain,which can result in microglial phagocytosis of live synapses and neurons that may contribute to cognitive deficits and neuronal loss.The microglial P2Y_(6) receptor(P2Y_(6)R)is a G-protein coupled receptor,which stimulates microglial phagocytosis when activated by extracellular uridine diphosphate,released by stressed neurons.Knockout or inhibition of P2Y_(6)R can prevent neu-ronal loss in mouse models of Alzheimer’s disease(AD),Parkinson’s disease,epilepsy,neuroinflammation and aging,and prevent cognitive deficits in models of AD,epilepsy and aging.This review summarises the known roles of P2Y_(6)R in the physiology and pathology of the brain,and its potential as a therapeutic target to prevent neurodegeneration and other brain pathologies.

关 键 词：Alzheimer’s disease Parkinson’s disease NEURODEGENERATION NEUROINFLAMMATION P2Y_(6)receptor Drug development MICROGLIA 

分 类 号：R741[医药卫生—神经病学与精神病学]