Cyclodextrin host-guest complex to facilitate sinomenine-based osteoporosis therapy  

作　　者：Meng-Qin Guo Ping Hu Zheng-Wei Huang 

机构地区：[1]College of Pharmacy,Jinan University,Guangzhou 511443,Guangdong Province,China

出　　处：《World Journal of Stem Cells》2025年第3期139-143,共5页世界干细胞杂志(英文)

基　　金：Supported by Guangdong Basic and Applied Basic Research Foundation,No.2024A1515011236;General Program of Administration of Traditional Chinese Medicine of Guangdong Province,No.20241071.

摘　　要：Xiao et al reported on the natural product sinomenine(SIN),which is a traditional Chinese medicine for treating osteoporosis via its modulation of autophagy;however,SIN was dissolved in dimethyl sulfoxide prior to administration,which is not conducive to the development of clinical injectables.By comparing solubilization techniques,including amorphisation,emulsification,micellisation,nanocrystallisation and host-guest inclusion,we found that the solubilization of SIN by host-guest inclusion can enhance solubility and improve stability and has an increased release rate and enhanced bioavailability.Therefore,we conclude that host-guest inclusion holds promise for SIN solubilization.To solubilise SIN,we selectedβ-cyclodextrin as the host agent considering its excellent biocompatibility,efficient encapsulation ability,mature preparation process and adequate drug stability.If the prerequisites of SIN-β-cyclodextrin complexes in terms of safety,efficacy,stability and the relevant laws and regulations are met,its clinical application for the treatment of osteoporosis may be achieved.

关 键 词：SINOMENINE CYCLODEXTRIN OSTEOPOROSIS AUTOPHAGY SOLUBILIZATION 

分 类 号：G63[文化科学—教育学]