Melanoma-derived extracellular vesicles transfer proangiogenic factors  

作　　者：MAGDALENA WILCZAK MAGDALENA SURMAN MAŁGORZATA PRZYBYŁO 

机构地区：[1]Department of Glycoconjugate Biochemistry,Faculty of Biology,Institute of Zoology and Biomedical Research,Jagiellonian University,Krakow,30-387,Poland [2]Doctoral School of Exact and Natural Sciences,Jagiellonian University,Krakow,30-348,Poland

出　　处：《Oncology Research》2025年第2期245-262,共18页肿瘤学研究(英文)

基　　金：supported by grants from the Jagiellonian University,Poland(N18/DBS/000007);the Polish National Science Centre(2018/31/N/NZ4/03787).

摘　　要：Angiogenesis,the expansion of pre-existing vascular networks,is crucial for normal organ growth and tissue repair,but is also involved in various pathologies,including inflammation,ischemia,diabetes,and cancer.In solid tumors,angiogenesis supports growth,nutrient delivery,waste removal,and metastasis.Tumors can induce angiogenesis through proangiogenic factors including VEGF,FGF-2,PDGF,angiopoietins,HGF,TNF,IL-6,SCF,tryptase,and chymase.This balance is disrupted in tumors,and extracellular vesicles(EVs)contribute to this by transferring proangiogenic factors and increasing their expression in endothelial cells(ECs).Malignant melanoma,a particular type of skin cancer,accounts for only 1%of skin cancer cases but more than 75%of deaths.Its incidence has risen significantly,with a 40%increase between 2012 and 2022,especially in fair-skinned populations.Advanced metastatic stages have a high mortality due to delayed diagnosis.This review examines the molecular basis of angiogenesis in melanoma,focusing on melanoma-derived EVs and their possible use in new antiangiogenic therapies.

关 键 词：Angiogenesis EXOSOMES Extracellular Vesicles(EVs) MELANOMA MICROVESICLES 

分 类 号：R73[医药卫生—肿瘤]