Two Cancers Arising from Different Mesenchymal Origins: An Unexpected Connection over Time and Space  

作　　者：Natascha Putri Sze Min Lek Nicholas Brian Shannon Joey Wee-Shan Tan Grace Hwei Ching Tan Claramae Shulyn Chia Melissa Ching Ching Teo Choon Hua Thng Timothy Kwang Yong Tay Chin-Ann Johnny Ong Tina Puay Theng Koh 

机构地区：[1]Division of Surgical Oncology, National Cancer Centre Singapore, Singapore City, Singapore [2]Division of Oncologic Imaging, National Cancer Centre Singapore, Singapore City, Singapore [3]Department of Anatomical Pathology, Singapore General Hospital, Singapore City, Singapore

出　　处：《Case Reports in Clinical Medicine》2019年第5期99-104,共6页临床医学病理报告（英文）

摘　　要：Sarcomas are rare tumours, accounting for 1% of all malignancies. They are histologically diverse, presenting with more than 50 different subtypes. Sarcoma can be broadly divided into two categories—soft tissue sarcoma and bone sarcoma. Extraskeletal osteosarcoma is a unique subtype which is histologically similar to bone osteosarcoma but resides within soft tissue and has no attachments to bone. We present a rare case of a patient who initially presented with an extraskeletal osteosarcoma that was complicated by a chronic chest wall sinus and lymphedema of the left arm. He later developed enlarging left chest wall nodules at the same region that were proven to be dedifferentiated liposarcoma on biopsy 20 years later. We examine the occurrence of both extremely rare diseases of differing pathologies over the same site but separated by an extraordinarily long interval, and possible new associations to account for this phenomenon.Sarcomas are rare tumours, accounting for 1% of all malignancies. They are histologically diverse, presenting with more than 50 different subtypes. Sarcoma can be broadly divided into two categories—soft tissue sarcoma and bone sarcoma. Extraskeletal osteosarcoma is a unique subtype which is histologically similar to bone osteosarcoma but resides within soft tissue and has no attachments to bone. We present a rare case of a patient who initially presented with an extraskeletal osteosarcoma that was complicated by a chronic chest wall sinus and lymphedema of the left arm. He later developed enlarging left chest wall nodules at the same region that were proven to be dedifferentiated liposarcoma on biopsy 20 years later. We examine the occurrence of both extremely rare diseases of differing pathologies over the same site but separated by an extraordinarily long interval, and possible new associations to account for this phenomenon.

关 键 词：SARCOMA EXTRASKELETAL OSTEOSARCOMA Dedifferentiated LIPOSARCOMA OSTEOGENIC SARCOMA 

分 类 号：R73[医药卫生—肿瘤]