Growth Hormone Replacement Therapy in Patients without Adult Growth Hormone Deficiency: What Answers Do We Have So Far?  

作　　者：Karine Rucker Larissa Bianca Paiva Cunha de Sá Alberto Krayyem Arbex 

机构地区：[1]Endocrinology Division, IPEMED Medical School, Sã o Paulo, Brazil [2]Diabetology Department, Malteser Krankenhaus St. Franziskus-Hospital, Flensburg, Germany

出　　处：《Health》2017年第5期799-810,共12页健康（英文）

摘　　要：Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) have been suggested as “anti-aging” therapies, or for improving quality of life with aging. In this study, we focus on the actions of GH in the main organs and organ systems of the human body, like skeletal muscle, bones and brain, particularly in regard to data and research on the use of GH replacement therapy in adults without growth hormone deficiency, especially elderly patients. Several different studies have been carried out to show what the effects and side effects of GH replacement in healthy people and what would be the impact in quality of life and life span. In this review, we demonstrate what answers we have so far about the effects of GH replacement in many organs and systems in healthy people.Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) have been suggested as “anti-aging” therapies, or for improving quality of life with aging. In this study, we focus on the actions of GH in the main organs and organ systems of the human body, like skeletal muscle, bones and brain, particularly in regard to data and research on the use of GH replacement therapy in adults without growth hormone deficiency, especially elderly patients. Several different studies have been carried out to show what the effects and side effects of GH replacement in healthy people and what would be the impact in quality of life and life span. In this review, we demonstrate what answers we have so far about the effects of GH replacement in many organs and systems in healthy people.

关 键 词：GROWTH HORMONE INSULIN-LIKE GROWTH Factor 1 SARCOPENIA GROWTH HORMONE Replacement Adult GROWTH HORMONE DEFICIENCY 

分 类 号：R73[医药卫生—肿瘤]