Anticonvulsant, Sedative and Antidepressant Effects of Aqueous Extract of Costus afer Stems in Mice  

作　　者：Bassoueka D’Avila Judicaël Peneme Bonaventure Max Lazard Ondele Radar Ahoudi Jered Abena Ange Antoine Bassoueka D’Avila Judicaël;Peneme Bonaventure Max Lazard;Ondele Radar;Ahoudi Jered;Abena Ange Antoine(Laboratory of Pharmacodynamics and Experimental Physiopathology (L2PE), Faculty of Sciences and Techniques, Marien Ngouabi University, Brazzaville, Republic of the Congo;Biochemistry and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of the Congo)

机构地区：[1]Laboratory of Pharmacodynamics and Experimental Physiopathology (L2PE), Faculty of Sciences and Techniques, Marien Ngouabi University, Brazzaville, Republic of the Congo [2]Biochemistry and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of the Congo

出　　处：《Journal of Biosciences and Medicines》2022年第12期22-31,共10页生物科学与医学（英文）

摘　　要：Epilepsy is a disorder in the nervous system which often causes a loss of consciousness. Traditional treatments are quiet a component of health care system in various populations in spite of the fact that well-established options are available. Most plants are used to treat epilepsy or those which have been verified for anticonvulsant activity were reported. Then, Costus afer is a plant of the Congolese flora used in traditional medicine for its many virtues. Therefore, the anticonvulsant activity of Costus afer was assessed with the strychnine convulsion induction test. Two tests were used for sedative activity such as the barbiturate sleep induction test and motor activity and finally the forced swimming test was also used to assess antidepressant activity. The results showed that the aqueous extract of Costus afer stems had no effects on strychnine-induced seizures at doses of 250 mg/kg and 500 mg/kg compared to the control group. However, the extract of Costus afer stems caused a very significant decrease in motricity at a dose of 500 mg/kg, showing a decrease in the onset time and a very significant increase in sleep duration like the reference molecule such as Diazepam. The aqueous extract of Costus afer stems also caused a decrease in immobility time in mice at a dose of 500 mg/kg.Epilepsy is a disorder in the nervous system which often causes a loss of consciousness. Traditional treatments are quiet a component of health care system in various populations in spite of the fact that well-established options are available. Most plants are used to treat epilepsy or those which have been verified for anticonvulsant activity were reported. Then, Costus afer is a plant of the Congolese flora used in traditional medicine for its many virtues. Therefore, the anticonvulsant activity of Costus afer was assessed with the strychnine convulsion induction test. Two tests were used for sedative activity such as the barbiturate sleep induction test and motor activity and finally the forced swimming test was also used to assess antidepressant activity. The results showed that the aqueous extract of Costus afer stems had no effects on strychnine-induced seizures at doses of 250 mg/kg and 500 mg/kg compared to the control group. However, the extract of Costus afer stems caused a very significant decrease in motricity at a dose of 500 mg/kg, showing a decrease in the onset time and a very significant increase in sleep duration like the reference molecule such as Diazepam. The aqueous extract of Costus afer stems also caused a decrease in immobility time in mice at a dose of 500 mg/kg.

关 键 词：EPILEPSY SEDATIVE Traditional Medicine ANTIDEPRESSANT ANTICONVULSANT 

分 类 号：R74[医药卫生—神经病学与精神病学]