Plant Digestive Supplement Designed by Lactobacillus Regulated Leukocyte Subsets through Activation of Complement Components and Implication for Use against Tumor Bearing Host against Infection  

作　　者：Kohji Ohtubo Nobuo Yamaguchi Nurmuhamamt Amat Dilxat Yimit Parida Hoxur Hiroshi Ushijima Yousuke Watanabe 

机构地区：[1]Ishikawa Natural Medicinal Products Research Center, Ishikawa, Japan [2]Department of Fundament Research for CAM, Kanazawa Medical University, Ishikawa, Japan [3]Traditional Uighur Medicine Department, Xinjiang Medical University, Urumqi, China [4]Traditional Chinese Medicine Hospital, Xinjiang Medical University, Urumqi, China

出　　处：《Open Journal of Immunology》2015年第3期133-146,共14页免疫学期刊（英文）

摘　　要：A plant material consisted by Family Poaceae was fermented by Yeast and Lactobaccilli (U-164). This material was proved by as safe in animal safety experiment for oral administration. In order to prove the effect of U-164 against physiological function, the animal and human trials were set up to look into mainly leukocyte functions. In animal experiment, anti-oxidative effect and antibody response in immune-compromised host and diabetes meritus were made up. For human use, peripheral lymphocyte in number and subset ratio were followed up to one month after administration. In order to understand its effect, human complement component analysis was made by immune-electrophoresis. Our results showed that U-164 augmented the level of lymphocytes, while U-164 down regulated the level of granulocytes. In our clinical study with 19 healthy volunteers, granulocyte and lymphocyte ratio was obtained as neutral in peripheral blood being increased significantly 30 days after the ingestion of U-164. In experimental animal study, the compromised host as well as normal animal was administered with cancer chemotherapeutic agent (Mytomycin-C). Our observations showed against antibody producing cell, this material recovered the antibody production in the host compromising the immure responsiveness. We also proposed an idea that U-164 exhibited tonic effects via activating complement components. Moreover, we tried to access further to the anti-oxidative activities of this U-164. This modification brought to the significant lifted up for anti-oxidative activity for phagocytic cell.A plant material consisted by Family Poaceae was fermented by Yeast and Lactobaccilli (U-164). This material was proved by as safe in animal safety experiment for oral administration. In order to prove the effect of U-164 against physiological function, the animal and human trials were set up to look into mainly leukocyte functions. In animal experiment, anti-oxidative effect and antibody response in immune-compromised host and diabetes meritus were made up. For human use, peripheral lymphocyte in number and subset ratio were followed up to one month after administration. In order to understand its effect, human complement component analysis was made by immune-electrophoresis. Our results showed that U-164 augmented the level of lymphocytes, while U-164 down regulated the level of granulocytes. In our clinical study with 19 healthy volunteers, granulocyte and lymphocyte ratio was obtained as neutral in peripheral blood being increased significantly 30 days after the ingestion of U-164. In experimental animal study, the compromised host as well as normal animal was administered with cancer chemotherapeutic agent (Mytomycin-C). Our observations showed against antibody producing cell, this material recovered the antibody production in the host compromising the immure responsiveness. We also proposed an idea that U-164 exhibited tonic effects via activating complement components. Moreover, we tried to access further to the anti-oxidative activities of this U-164. This modification brought to the significant lifted up for anti-oxidative activity for phagocytic cell.

关 键 词：Family Poaceae Fermentation Yeast LACTOBACILLUS Cancer CHEMOTHERAPEUTIC Agent Compromised HOST COMPLEMENT C3B Fragment Anti-Oxidant Diabetes Blood Sugar 

分 类 号：R73[医药卫生—肿瘤]