Anti-Aging of Our Optic Nerve-Dream or Reality?—Impact of Macrophage Activation and Resveratol on Optic Nerve Health  

作　　者：Sylvia Paulig Martin Krause Sylvia Paulig;Martin Krause(Paulig Eye & Health, Berlin, Germany)

机构地区：[1]Paulig Eye & Health, Berlin, Germany

出　　处：《Open Journal of Ophthalmology》2024年第4期428-433,共6页眼科学期刊（英文）

摘　　要：This paper presents findings on the potential of combining Selective Laser Trabeculoplasty (SLT) with Resveratrol supplementation to treat optic nerve degeneration in glaucoma patients. Glaucoma is a multifactorial disease where IOP-lowering therapies often fail to halt progression, especially in low-tension glaucoma cases. SLT activates macrophages, promoting cleaning of the trabecular meshwork, while Resveratrol enhances mitochondrial function, reduces oxidative stress, and supports optic nerve regeneration. Our results from over 12,000 patients show that this integrative approach improves optic nerve health, particularly in patients with normal IOP.This paper presents findings on the potential of combining Selective Laser Trabeculoplasty (SLT) with Resveratrol supplementation to treat optic nerve degeneration in glaucoma patients. Glaucoma is a multifactorial disease where IOP-lowering therapies often fail to halt progression, especially in low-tension glaucoma cases. SLT activates macrophages, promoting cleaning of the trabecular meshwork, while Resveratrol enhances mitochondrial function, reduces oxidative stress, and supports optic nerve regeneration. Our results from over 12,000 patients show that this integrative approach improves optic nerve health, particularly in patients with normal IOP.

关 键 词：GLAUCOMA Optic Nerve SLT RESVERATROL MITOCHONDRIA Autophagy AMPK Pathway 

分 类 号：R73[医药卫生—肿瘤]