Synthesis and Determination of Antitumor Activity of Jacaranone and Synthetic Analogs  

作　　者：María L. Arias Eugenia Corrales Rebeca Poveda Jorge A. Cabezas 

机构地区：[1]ResearchCenter for Tropical Disease (CIET) and Faculty of Microbiology, University of Costa Rica, San José, Costa Rica [2]School of Chemistry, University of Costa Rica, San José, Costa Rica

出　　处：《International Journal of Organic Chemistry》2018年第1期115-124,共10页有机化学国际期刊（英文）

摘　　要：Natural product jacaranone, 1, and three analog derivatives were synthesized and their apoptotic and necrotic activity against four cancer cell lines was tested. One of these derivatives 7, was more active than the natural product, and exhibited an important necrotic effect against three of the cell lines tested (ovarian carcinoma, liver cancer and breast cancer cells). Derivative 6 was more active than the natural product, and showed a significant apoptotic activity against breast cancer and ovarian carcinoma cells. Some derivatives analyzed in this study showed promising anti-tumor results, nevertheless, further studies have to be done in order to determine their in vivo activity, their mechanism as well as their safety and stability.Natural product jacaranone, 1, and three analog derivatives were synthesized and their apoptotic and necrotic activity against four cancer cell lines was tested. One of these derivatives 7, was more active than the natural product, and exhibited an important necrotic effect against three of the cell lines tested (ovarian carcinoma, liver cancer and breast cancer cells). Derivative 6 was more active than the natural product, and showed a significant apoptotic activity against breast cancer and ovarian carcinoma cells. Some derivatives analyzed in this study showed promising anti-tumor results, nevertheless, further studies have to be done in order to determine their in vivo activity, their mechanism as well as their safety and stability.

关 键 词：Jacaranone Jacaranone SYNTHETIC ANALOGS ANTITUMOR ACTIVITY 

分 类 号：R73[医药卫生—肿瘤]