Patterns of synuclein expression throughout lens development  

作　　者：Irina Surgucheva Belinda MacMahon Andrei Surguchov 

机构地区：[1]Retinal Biology Research Laboratory, Veterans Administration Medical Center, Kansas City, USA [2]Washington University, St. Louis, USA

出　　处：《Journal of Biophysical Chemistry》2010年第1期12-18,共7页生物物理化学（英文）

摘　　要：Synucleins belong to a family of small soluble proteins with chaperonic activity implicated in human diseases, but their normal function is not completely understood. Expression of ?, ? and ?-synucleins was analyzed in rat and human lens on different stages of development. No significant expression of ?- and ?-synucleins were found, whereas ?-synuclein was expressed in both species only on early stages of lens development. Examination of ?-synuclein upstream region demonstrated the similarity in its organization with promoter regions of crystallins and heat shock protein’s genes. ?-Synuclein upstream region contains motives identical or similar to regulatory cis-elements in their promoters including binding sites for Pax6 and Sox. These results suggest that ?-synuclein plays a role in distinct temporal events in lens development, presumably acting as a specific chaperone.Synucleins belong to a family of small soluble proteins with chaperonic activity implicated in human diseases, but their normal function is not completely understood. Expression of ?, ? and ?-synucleins was analyzed in rat and human lens on different stages of development. No significant expression of ?- and ?-synucleins were found, whereas ?-synuclein was expressed in both species only on early stages of lens development. Examination of ?-synuclein upstream region demonstrated the similarity in its organization with promoter regions of crystallins and heat shock protein’s genes. ?-Synuclein upstream region contains motives identical or similar to regulatory cis-elements in their promoters including binding sites for Pax6 and Sox. These results suggest that ?-synuclein plays a role in distinct temporal events in lens development, presumably acting as a specific chaperone.

关 键 词：Lens CRYSTALLINS Synucleins PROMOTER CHAPERONES Heat Shock PROTEINS 

分 类 号：R73[医药卫生—肿瘤]