国家自然科学基金(81230061)

作品数：9被引量：141H指数：5
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相关机构：中国人民解放军总医院中国人民解放军海军总医院更多>>
相关期刊：《转化医学杂志》《Science Bulletin》《Science China(Life Sciences)》《Signal Transduction and Targeted Therapy》更多>>
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Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo被引量：15
《Protein & Cell》2018年第10期867-878,共12页Yanjing Song Chuan Tong Yao Wang Yunhe Gao Hanren Dai Yelei Guo Xudong Zhao Yi Wang Zizheng Wang Weidong Han Lin Chen 
The authors thank all patients who participated and their families, as well as the investigators and staff at this study for their valuable contribution to this study. We＇d like to give a special thanks to Zhiqiang Wu for the construction of plasmids. This study was supported by grants from the National Natural Science Foundation of China （Grant Nos. 81230061, 81402566, 81672319, 81602507, and 81602711）, the Science and Technology Planning Project of Beijing City （No. Z151100003915076） and the key Nursery Project of Chinese PLA General Hospital （16KMZ05） and was partially supported by a grant from the National Basic Science and Development Programme of China （No. 2013BAI01B04）.
Human epidermal growth factor receptor 2 （HER2） pro- teins are overexpressed in a high proportion of gastric cancer （GC） cases and affect the maintenance of cancer stem cell （CSC） subpopulations, which are used ...
关键词：chimeric antigen receptor HER2 gastriccancer cancer stem cell CD137 IMMUNOTHERAPY 
DNA methylation-mediated repression of miR-181a/135a/302c expression promotes the microsatellite-unstable colorectal cancer development and 5-FU resistance via targeting PLAG1被引量：9
《Journal of Genetics and Genomics》2018年第4期205-214,共10页Lu Shi Xiang Li Zhiqiang Wu Xiaolei Li Jing Nie Mingzhou Guo Qian Mei Weidong Han 
supported by the National Key Research and Development Program of China (2016YFC1303501 and 2016YFC1303504);the National Natural Science Foundation of China (Nos. 81572914 and 81230061)
Micro sate Hite instability（MSI） defines a subtype of colorectal cancer（CRC） with typical clinicopathologic characteristics. CRCs with MSI（MSI CRCs） frequently acquire accelerated carcinogenesis and 5-FU resista...
关键词：Colorectal cancer Microsatellite instability microRNA PLAG1 Chemoresistance 5-FU 
Innovative and propagable translational research model established for cell-based therapy at Chinese PLA General Hospital被引量：1
《Science China(Life Sciences)》2016年第10期1063-1067,共5页Weidong Han Xiaobing Fu 
supported by the National Natural Science Foundation of China(81230061,81121004,and 81230041);the Military Medical Foundation(AWS11J008);the National Basic Research Program of China(2012CB518105)
The use of translational medicine in Chinese hospitals ap- pears to have become easier over the last decade. Products developed in the laboratory can sometimes be applied in the clinic under life-saving circumstances....
关键词：中国人民解放军 细胞疗法 转化 医院 模型 创新 实验室 应用 
Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer被引量：66
《Science China(Life Sciences)》2016年第5期468-479,共12页Kaichao Feng Yelei Guo Hanren Dai Yao Wang Xiang Li Hejin Jia Weidong Han 
supported by the Science and Technology Planning Project of Beijing City (Z151100003915076);the National Natural Science Foundation of China (31270820, 81230061, 81472612, 81402566);the National Basic Science and Development Programme of China (2013BAI01B04);the Nursery Innovation Fund (15KMM50)
The successes achieved by chimeric antigen receptor-modified T （CAR-T） cells in hematological malignancies raised the pos- sibility of their use in non-small lung cancer （NSCLC）. In this phase I clinical study （N...
关键词：chimeric antigen receptor IMMUNOTHERAPY epidermal growth factor receptor RELAPSED/REFRACTORY non-small cell lungcancer 
Treatment of CD20-directed Chimeric Antigen Receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma:an early phase IIa trial report被引量：12
《Signal Transduction and Targeted Therapy》2016年第1期131-139,共9页Wen-ying Zhang Yao Wang Ye-lei Guo Han-ren Dai Qing-ming Yang Ya-jing Zhang Yan Zhang Mei-xia Chen Chun-meng Wang Kai-chao Feng Su-xia Li Yang Liu Feng-xia Shi Can Luo Wei-dong Han 
This study was supported by the grants from the National Natural Science Foundation of China(Nos.31270820,81230061,81121004 and 81402566);was partially supported by a grant from the National Basic Science and Development Programme of China(Nos.2012CB518103,2012AA020502 and 2013BAI01B00).
Patients with relapsed or refractory non-Hodgkin lymphoma have a dismal prognosis.Chimeric Antigen Receptor(CAR)-modified T cells(CART cells)that targeted CD20 were effective in a phase I clinical trial for patients w...
关键词：PATIENTS LYMPHOMA ANTIGEN 
Cytokine-induced killer (ClK) cells:from basic research to clinical translation被引量：33
《Chinese Journal of Cancer》2015年第3期99-107,共9页Yelei Guo Weidong Han 
supported by the grants from the National Natural Science Foundation of China(31270820,81230061 and 81402566);partially supported by a grant from the 2013BA101B00
The accumulation of basic researches and clinical studies related to cytokine-induced killer(CIK) cells has confirmed their safety and feasibility in treating malignant diseases.This review summarizes the available pu...
关键词：细胞因子 临床应用 基础研究 CLK 杀伤 诱导 恶性肿瘤细胞 翻译 
Microenvironment-induced myofibroblast-like conversion of engrafted keratinocytes被引量：4
《Science China(Life Sciences)》2014年第2期209-220,共12页LI MeiRong TI DongDong HAN WeiDong FU XiaoBing 
supported in part by the National Natural Science Foundation of China(3127082,81230061,81121004,81201479);National Basic Research Program of China(2012CB518103,2012CB518105);National High Technology Research and Development Program of Ministry of Science and Technology of China(2011AA020113,2012AA020502,2013AA020105)
Myofibroblasts,recognized classically by-smooth muscle actin(-SMA)expression,play a key role in the wound-healing process,promoting wound closure and matrix deposition.Although a body of evidence shows that keratinocy...
关键词：epithelial-mesenchymal transition epithelial-myofibroblast transition keratinocyte-myofibroblast transition myofi-broblast wound healing 
细胞因子诱导的杀伤细胞在早期肾癌术后治疗中的应用被引量：5
《转化医学杂志》2013年第3期156-159,162,共5页王津 江朝光 韩为东 王瑶 卢学春 刘洋 张宝和 胡志 王吉 张燕 丰恺超 张文英 陈美霞 汪宣驰 
国家自然科学基金重点项目(81230061)
目的观察早期肾癌根治术后行自体细胞因子诱导的杀伤(cytokine-induced killer,CIK)细胞治疗的临床疗效。方法选取解放军总医院2009年期间Ⅰ、Ⅱ期肾癌术后患者40例,治疗组20例采自体外周CIK细胞血进行CIK细胞扩增,采取静脉回输方法治疗...
关键词：肾肿瘤 杀伤细胞 免疫疗法 
The macrodomain family:Rethinking an ancient domain from evolutionary perspectives
《Chinese Science Bulletin》2013年第9期953-960,共8页LI XiaoLei WU ZhiQiang HAN WeiDong 
supported by the National Natural Science Foundation of China(31201033,31270820,81071617 and 81230061);the Ministry of Science and Technology of China(2012CB518103 and 2012CB518105)
The reasons why certain domains evolve much slower than others is unclear.The notion that functionally more important genes evolve more slowly than less important genes is one of the few commonly believed principles o...
关键词：基因进化 宏畴 家庭 DNA损伤 染色质重塑 生物学分析 功能多样性 分子进化 
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