国家自然科学基金(s)

作品数:37被引量:95H指数:5
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相关作者:刘国栋万齐欣彭建飞熊志华汪胜前更多>>
相关机构:东南大学江西科技师范学院浙江理工大学更多>>
相关期刊:《Magnetic Resonance Letters》《Science Bulletin》《Advances in Polar Science》《npj Flexible Electronics》更多>>
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Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1
《Acta Pharmacologica Sinica》2023年第4期801-810,共10页Zuo-wei Wang Feng-ming Zou Ao-li Wang Jing Yang Rui Jin Bei-lei Wang Li-juan Shen Shuang Qi Juan Liu Jing Liu Wen-chao Wang Qing-song Liu 
supported by the National Natural Science Foundation of China(Grant Nos,32171479,82104198,82103976);the Natural Science Foundation of Anhui Province(Grant No,2108085QH377);the China Postdoctoral Science Foundation(Grant No.2020M671916);the Collaborative Innovation Program of Hefei Science Center,CAS(Grant No.2021HSC-CIP014);the Frontier Science Key Research Program of CAS(Grant QYZDB-SSW-SLH037);the CASHIPS Director's Fund(Grant Nos.YZJZX202011,YZJJ2022QN41,YZJJ2021QN38);support of theYouth Innovation Promotion Association of CAS support(No.2022453)for JY;A portion of this work was supported by the High Magnetic Field Laboratory of Anhui Province.
Necroptosis is a form of regulated necrosis involved in various pathological diseases.The process of necroptosis is controlled by receptor-interacting kinase 1(RIPK1),RIPK3,and pseudokinase mixed lineage kinase domain...
关键词:AZD4547 RIPK1 INHIBITORS SIRS model anti-necroptosis 
Boosting photocatalytic hydrogen production via interfacial engineering over a Z-scheme core/shell heterojunction
《Nano Research》2023年第1期352-359,共8页Bing Luo Jinghua Li Wei Wang Chaoqian Ai Haihan Zhang Yuxin Zhao Dengwei Jing 
This work was financially supported by the National Key Research and Development Program of China(No.2018YFB1502000);the National Natural Science Foundation of China(Nos,62074123 and 52106270);the PetroChina Innovation Foundation(No.2019D-5007-0410);the Young Talent Support Plan of Xi'an Jiaotong University(No.7121191202);the Natural Science Foundation of Shaanxi Province(No.2021JQ-040);the China Postdoctoral Science Foundation(No.2020M683472).
Designing high efficacy photocatalysts is a promising way to improve solar fuel production efficiency.In this work,we prepared a core/shell composite of loose ZnCr layered double hydroxide nanosheets modified CdS nano...
关键词:photocatalysis HETEROJUNCTION interfacial engineering noble metal free hydrogen production 
Heteronuclear-filtered ^(1)H homonuclear multi-quantum correlation experiment at 100 kHz magic-angle spinning Dedicated to Professor Chaohui Ye on the occasion of his 80th birthday
《Magnetic Resonance Letters》2022年第4期266-275,共10页Mingji Zheng Shuangqin Zeng Xiumei Wang Xiuzhi Gao Qiang Wang Jun Xu Feng Deng 
the National Natural Science Foundation of China(Grants,22161132028,221721177,22127801,U1932218 and 21733013);Hubei Provincial Natural Science Foundation(2021CFA021);Youth Innovation Promotion Association,Chinese Academy of Sciences(2019326)。
Remarkable advances in fast magic-angle spinning(MAS)techniques significantly improve the resolution of^(1)H solid-state nuclear magnetic resonance(NMR)spectra.Here,we introduce a heteronuclear-filtered^(1)H homonucle...
关键词:Solid-state NMR spectroscopy Proton Heteronuclear filter Homonuclear correlation Multi-quantum Ultra-fast magic angle spinning 
Soft,stretchable thermal protective substrates for wearable electronics
《npj Flexible Electronics》2022年第1期401-409,共9页Shuang Nie Min Cai Huang Yang Liyin Shen Suhao Wang Yang Zhu Jizhou Song 
support of the National Natural Science Foundation of China (Grant Nos,U20A6001 and 11872331);National Key Research and Development Program of China (Grant No,2019YFE0117400);Zhejiang University K.P.Chao’s High Technology Development Foundation.
Wearable electronics have continued to attract the attention of researchers and clinicians due to their great potential in medical applications.During their operations,the undesired heating may cause thermal discomfor...
关键词:WEAR protective THERMAL 
Enhancing the high-temperature creep properties of Mo alloys via nanosized La_(2)O_(3) particle addition被引量:1
《Journal of Materials Science & Technology》2022年第35期53-63,共11页P.M.Cheng C.Yang P.Zhang J.Y.Zhang H.Wang J.Kuang G.Liu J.Sun 
supported by the National Natural Science Foundation of China (Grant Nos.,51801147,and 51901173);supported by the International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies。
Molybdenum(Mo) alloys with different La_(2)O_(3)particle additions(0.6,0.9,1.5 wt.%) were prepared by powder metallurgy to investigate the effect of La_(2)O_(3)particles on microstructural evolution and creep behavior...
关键词:Mo alloys Nanosized particles Creep strength Deformation and fracture 
Accelerating temporal action proposal generation via high performance computing
《Frontiers of Computer Science》2022年第4期59-68,共10页Tian Wang Shiye Lei Youyou Jiang Choi Chang Hichem Snoussi Guangcun Shan Yao Fu 
supported by the National Key Research and Development Program of China(2016YFE0204200);the National Natural Science Foundation of China(Grant Nos,61972016,62032016);Bejing Natural Science Foundation(L191007);the Fundamental Research Funds for the Central Universities(YWF-21-BJ-J-313 and YWF-20-BJ-J-612);Open Research Fund of Digital Fujian Environment Monitoring Internet of Things Laboratory Foundation(202004).
Temporal action proposal generation aims to output the starting and ending times of each potential action for long videos and often suffers from high computation cost.To address the issue,we propose a new temporal con...
关键词:temporal convolution temporal action proposal generation deep learning 
The origin of unwanted editing byproducts in gene editing被引量:1
《Acta Biochimica et Biophysica Sinica》2022年第6期767-781,共15页Jianhang Yin Jiazhi Hu 
the grants from the National Key R&D Program of China(No.,2017YFA0506700);the National Natural Science Fundition of China(Nos.,32122018,31771485);the SLS-Qidong Innovation Fund;the PKU-TSU Center for Life Sciences.
The rapid development of CRISPR-Cas genome editing tools has greatly changed the way to conduct research and holds tremendous promise for clinical applications. During genome editing, CRISPR-Cas enzymes induce DNA bre...
关键词:genome editing and CRISPR/Cas DSB repair chromosomal translocation large deletion vector DNA integration PEM-seq 
Alternative end-joining in BCR gene rearrangements and translocations被引量:2
《Acta Biochimica et Biophysica Sinica》2022年第6期782-795,共14页Wanyu Bai Bo Zhao Mingyu Gu Junchao Dong 
the grants from the National Natural Science Foundation of China(Nos.,81871304,32070892);Guangdong Innovative and Entrepreneurial Research Team Program(No.,2016ZT06S252);Guangzhou Municipal Science and Technology Bureau(No.,202002030064);the Fundamental Research Funds for the Central Universities(No.,18ykzd11);Sanming Project of Medicine in Shenzhen(No.,SZSM202011004);Open project of Key Laboratory of Tropical Disease Control(Sun,Yat-sen,University);Ministry of Education(No.,2020ZX01)。
Programmed DNA double-strand breaks(DSBs)occur during antigen receptor gene recombination,namely V(D)J recombination in developing B lymphocytes and class switch recombination(CSR)in mature B cells.Repair of these DSB...
关键词:classical nonhomologous end-joining alternative end-joining V(D)J recombination chromosomal translocation DSB end resection ENDONUCLEASE 
Contribution of rare mutational outcomes to broadly neutralizing antibodies被引量:2
《Acta Biochimica et Biophysica Sinica》2022年第6期820-827,共8页Anqi Feng Qian Hao Leng-Siew Yeap 
the grants from the National Key R&D Program of China(Nos.,2020YFA0112900,2021YFA1301400);the National Natural Science Foundation of China(Nos.,31722020,81671634,81861138014);the China Postdoctoral Science Foundation(Nos.,2016M601613,BX201600107,to,Q.H.)。
Antibodies are important immune molecules that are elicited by B cells to protect our bodies during viral infections or vaccinations. In humans, the antibody repertoire is diversified by programmed DNA lesion processe...
关键词:somatic hypermutation AID broadly neutralizing antibodies INDELS ong CDR H3 
Hybrid deep learning model for risk prediction of fracture in patients with diabetes and osteoporosis被引量:2
《Frontiers of Medicine》2022年第3期496-506,共11页Yaxin Chen Tianyi Yang Xiaofeng Gao Ajing Xu 
supported by the National Key R&D Program of China(Nos.2020YFC2005502 and 2018YFB 1004700);the National Natural Science Foundation of China(Nos,6187238 and 61972254);the Science and Technology Commission of Shanghai Municipality No.19401900500)the Innovation Program of Shanghai Health Commission(Nos.201840121 and ZY(2018-2020)-ZWB-1001-CPJS1);the CCF-Huawei Database System Innovation Research Plan(No.CCF-Huawei DBIR2019002A);and the program of Hospital Clinical Research,Xinhua Hospital Afiliated to Shanghai Jiao Tong University School of Medicine(No.19XHCR11C).
The fracture risk of patients with diabetes is higher than those of patients without diabetes due to hyperglycemia,usage of diabetes drugs,changes in insulin levels,and excretion,and this risk begins as early as adole...
关键词:XGBoost deep neural network healthcare risk prediction 
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