国家自然科学基金(30970125)

作品数：8被引量：37H指数：4
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相关作者：宋有涛钟正伟沈曼莉孙晓霞更多>>
相关机构：辽宁大学承德石油高等专科学校更多>>
相关期刊：《Asian Pacific Journal of Tropical Medicine》《辽宁大学学报（自然科学版）》《中国人兽共患病学报》《Acta Biochimica et Biophysica Sinica》更多>>
相关主题：LEPTOSPIRAPATIENTSMICROBIOTASPUTUM朊病毒更多>>
相关领域：农业科学生物学医药卫生轻工技术与工程更多>>
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Re-characterization of an extrachromosomal circular plasmid in the pathogenic Leptospira interrogans serovar Lai strain 56601被引量：1
《Acta Biochimica et Biophysica Sinica》2014年第7期605-611,共7页Lili Huang Weinan Zhui Ping He Yan Zhang Xuran Zhuang Guoping Zhao Xiaokui Guo Jinhong Qin Yongzhang Zhu 
This work was supported in part by the grants from the National Natural Science Foundation of China （30770820, 30970125,81101264, and 81171587） and the National Key Program for Infectious Diseases of China （2009ZX10004-712）.
In China, Leptospira interrogans serovar Lai strain 56601 （str.56601） is one of main pathogenic strains that cause severe leptospirosis in both human and animals. The genome of this organism was completely sequenced...
关键词：genomic island Leptospira interrogans extrachromosomal circular plasmid 
An Outbreak of Leptospirosis in Lezhi County, China in 2010 May Possibly Be Linked to Rainfall被引量：4
《Biomedical and Environmental Sciences》2014年第1期56-59,共4页WANG Ya Lin QIN Jin Hong ZHANG Cui Cai GUO Xiao Kui JIANG Xiu Gao HE Ping 
supported by grants from the National Natural Science Foundation of China(30970125,81101264,and 81171587)
A total of 26 leptospirosis cases occurred in the outbreak, of whom six died after hospitalization. All 26 patients were clinically diagnosed as leptospirosis Microscopic agglutination test （MAT） revealed that 13 of...
关键词：2010 China in 2010 May Possibly Be Linked to Rainfall An Outbreak of Leptospirosis in Lezhi County 
New microbiota found in sputum from patients with community-acquired pneumonia被引量：3
《Acta Biochimica et Biophysica Sinica》2013年第12期1039-1048,共10页Chunyan Chen Tian Shen Fei Tian Ping Lin Qingtian Li Zelin Cui Yajuan Zhang Min Xue Jing Ye Xiaokui Guo Yuhua Zhou 
This work was supported by grants from the National Natural Science Foundation of China （30770111, 30900051, 30970125）, the National Key Program for Infectious Diseases of China （2008ZX 10004-002, 2008ZX 10004-009, and 2009ZX10004-712）, and the Program of Shanghai Subject Chief Scientist （09XD 1402700）.
Community-acquired pneumonia （CAP） is a major concern in hospitals and the bacterial community of which has not been systemically discussed yet. Sputum from patients in the acute stages is a kind of accessible sampl...
关键词：16s ribosomal DNA MICROBIOTA community-acquired pneumonia PYROSEQUENCING SPUTUM 
疯牛病防治的研究进展被引量：2
《辽宁大学学报（自然科学版）》2012年第1期1-7,共7页沈曼莉 孙晓霞 宋有涛 
国家自然科学基金(30970125);教育部人文社会科学研究青年基金(08JC790053);辽宁大学韩国高等教育财团项目(H07Y01)资助
疯牛病是由朊病毒引起的一种致死性人畜共患神经退行性疾病.根据近年来国际上有关疯牛病防治的研究进展,并结合本课题组最近在该领域的研究成果,以新的角度,主要从疯牛病的风险因素、演化、种间传播、防治药物和监控体系等方面做以综述...
关键词：疯牛病 防治 朊病毒 种属屏障 
High prevalence of pathogenic Leptospira in wild and domesticated animals in an endemic area of China被引量：4
《Asian Pacific Journal of Tropical Medicine》2011年第11期841-845,共5页Wang Yalin Zeng Lingbing Yang Hongliang Xu Jianmin Zhang Xiangyan Guo Xiaokui Pal Utpal Qin Jinhong 
supported by grants from,the National Natural Science Foundation of China(30970125,81101264 and 811715871);the Program of Shanghai Health Bureau(2008045)
Objective:To assess the prevalence of Leptospira detected in wildlife and domesticated animals in Jiangxi Province,China,in 2009.Methods:Urine samples from 28 buffaloes and kidney samples from 50 pigs,50 dogs and 38 r...
关键词：LEPTOSPIROSIS PREVALENCE China PCR Culture Reservoir 
朊病毒治疗候选药物的研究进展被引量：7
《中国人兽共患病学报》2011年第9期828-835,共8页钟正伟 宋有涛 
国家自然科学基金项目(30970125);教育部人文社会科学研究青年基金(08JC790053);辽宁省教育厅优秀人才计划(2009R26)
疯牛病（BSE）、羊瘙痒症（scrapie）、人库鲁病（kuru）和人克雅氏症（CJD）等都是由朊病毒（prion）引起的一类具有高度传染性和致死性的中枢神经系统疾病。研究表明,细胞内正常朊病毒（PrPC）是一种广泛地表达于脊椎动物细胞表面的...
关键词：正常朊病毒 病毒治疗 糖基化磷脂酰肌醇锚定蛋白 中枢神经系统疾病 药物 候选 克雅氏症 人库鲁病 
Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601被引量：10
《Cell Research》2011年第8期1210-1229,共20页Yi Zhong Xiao Chang Xing-Jun Cao Yan Zhang Huajun Zheng Yongzhang Zhu Chengsong Cai Zelin Cui Yunyi Zhang Yuan-Yuan Li Xiu-Gao Jiang Guo-Ping Zhao Shengyue Wang Yixue Li Rong Zeng Xuan Li Xiao-Kui Guo 
We thank Professor M Picardeau for the gift ofL. interrogans strain IPAV and Bao-Yu Hu and Yang Yang for the support in performing bacteria culture. We also thank Dr Junwei Yang for suggestions in revising the manuscript. We thank the genome sequencing team at Chinese Human Genome Center at Shanghai for their assistance. This work was supported in part by grants from the National Natural Science Foundation of China （30770111, 30900051 and 30970125）, the National Key Program for Infectious Diseases of China （2008ZX10004 and 2009ZX10004）, the Program of Shanghai Subject Chief Scientist （09XD 1402700） and the Program of Shanghai Research and Development （10JC 1408200）.
The virulence-attenuated Leptospira interrogans serovar Lai strain IPAV was derived by prolonged laboratory passage from a highly virulent ancestral strain isolated in China. We studied the genetic variations of IPAV ...
关键词：GENOME PROTEOME LEPTOSPIRA VIRULENCE MUTATION 
Analysis of the microbiota of sputum samples from patients with lower respiratory tract infections被引量：8
《Acta Biochimica et Biophysica Sinica》2010年第10期754-761,共8页Yuhua Zhou Ping Lin Qingtian Li Lizhong Han Huajun Zheng Yanxia Wei Zelin Cui Yuxing Ni Xiaokui Guo 
This work was supported by grants from the National Natural Science Foundation of China （30770111, 30900051, and 30970125）, the National Key Program for Infectious Diseases of China （2008ZX10004 and 2009ZX10004）, the Program of Shanghai Subject Chief Scientist （09XD1402700）, and the Program of Shanghai Research and Development （10JC 1408200）.
Sputum is the most common sample collected from patients suffering from lower respiratory tract infections and it is crucial for the bacterial identification of these infections. In this study, we enrolled 101 sput...
关键词：16S ribosomal DNA lower respiratoryinfection MICROBIOTA pyrosequence SPUTUM 
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