This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81001464, 81373409, and 81673491), the Natural Science Foundation of Hunan Province (Nos. 2015JJ3140, 2015JJ2150, and 13JJ2008), and the Teacher's Funding of Central South University (No. 2014JSJJ029).
Recent studies revealed that sirtuin 1 (SIRT1) is involved in the regulation of energy metabolism and its agonist resveratrol showed anti-obesity effect. This study aims to determine whether BTM- 0512, a novel deriv...