supported,in part,by grants from the National Natural Science Foundation(Nos.81130035,30901561,30971192,81071545);the National Basic Research Program of China(No.2012CB518102);the China Postdoctoral Science Foundation(Nos.20100480347,201104125)
High mobility group box 1 protein (HMGB1) is a highly conserved, ubiquitous protein in the nuclei and cytoplasm of nearly all cell types. HMGB1 is secreted into the extracellular milieu and acts as a proinflammatory...