国家自然科学基金(31271227)

作品数：7被引量：26H指数：2
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相关作者：刘德培陈厚早李红良韦玉生付文艳更多>>
相关机构：中国医学科学院基础医学研究所中国医学科学院北京协和医学院更多>>
相关期刊：《Science China(Life Sciences)》《中国科学：生命科学》《Chinese Medical Sciences Journal》更多>>
相关主题：SIRT1OVEREXPRESSIONICAM-1PMAIONOMYCIN更多>>
相关领域：医药卫生更多>>
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Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice被引量：2
《Science China(Life Sciences)》2016年第11期1115-1122,共8页Jian-Fei Pei Yun-Fei Yan Xiaoqiang Tang Yang Zhang Shen-Shen Cui Zhu-Qin Zhang Hou-Zao Chen De-Pei Liu 
supported by the National Natural Science Foundation of China(81422002,91339201,31271227,31571193);the National Science and Technology Support Project(2013YQ0309230502,2014BAI02B01);the Beijing Nova Program(XX2013064)
Cardiac hypertrophy is the strongest predictor of the development of heart failure, and anti-hypertrophic treatment holds the key to improving the clinical syndrome and increasing the survival rates for heart failure....
关键词：cardiac hypertrophy FIBROSIS paraoxonase gene cluster angiotensin II 
Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure被引量：13
《Science China(Life Sciences)》2014年第9期915-924,共10页MU WenLi ZHANG QingJun TANG XiaoQiang FU WenYan ZHENG Wei LU YunBiao LI HongLiang WEI YuSheng LI Li SHE ZhiGang CHEN HouZao LIU DePei 
supported by the National Natural Science Foundation of China(31271227,81161120551);the National Basic Research Program of China(2011CB503902)
SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation of vascular function.The current study aims to investigate...
关键词：DEACETYLASE SIRT1 apoptosis heart failure 
小鼠心脏过表达SIRT1显性失活突变体导致心肌细胞凋亡和早发性心衰被引量：2
《中国科学：生命科学》2014年第9期861-870,共10页穆文利 张庆军 唐小强 付文艳 郑伟 鲁云彪 李红良 韦玉生 折志刚 陈厚早 刘德培 
国家自然科学基金(批准号:31271227,81161120551);国家重点基础研究发展计划(批准号:2011CB503902)资助项目
本研究旨在探究SIRT1的去乙酰化活性在调节心脏功能方面的重要作用.与成年小鼠心脏相比,在出生后早期小鼠的心脏中SIRT1去乙酰化活性较高.为了进一步研究SIRT1酶活性在出生后心脏中的功能,本研究构建了心脏特异性表达人源SIRT1显性失活...
关键词：去乙酰化 SIRT1 凋亡 心衰 
Mechanistic perspectives of calorie restriction on vascular homeostasis
《Science China(Life Sciences)》2014年第8期742-754,共13页LIU Yue CHEN HouZao LIU DePei 
supported by the National Natural Science Foundation of China (31271227,91339201);the Beijing Nova Program (XX2013064);the National Basic Research Program of China (2011CB503902)
Calorie restriction(CR)is a dietary regime based on low calorie intake.CR without malnutrition extends lifespan in a wide range of organisms from yeast to rodents,and CR can prevent and delay the onset of age-related ...
关键词：calorie restriction（CR） vascular homeostasis Sirtuin 1（SIRT1） AMP-activated protein kinase（AMPK） mammalian target of rapamycin（mTOR） endothelial nitric oxide synthase（eNOS） 
Lysine-specific Demethylase 1 Represses THP-1 Monocyte-to-macrophage Differentiation
《Chinese Medical Sciences Journal》2013年第2期82-87,共6页Rui-feng Yang Guo-wei Zhao Shu-ting Liang Hou-zao Chen De-pei Liu 
Supported by National Natural Science Foundation of China(31271227,30721063,81161120551);National Basic Research Program of China(973 Program,2011CB503902,2011CB965203)
Objective To investigate the role of lysine-specific demethylase 1 （LSD1） in the process of THP-1 monocyte-to-macrophage differentiation. Methods Quantitative reverse transcription-polymerase chain reaction （qRT-...
关键词：lysine-specific demethylase 1 INTERLEUKIN-6 H3K4 methylation monocyte-to-macrophage differentiation 
SIRT1在内皮细胞中抑制PMA和ionomycin诱导的ICAM-1的表达
《中国科学：生命科学》2013年第2期112-118,共7页贾玉艳 高鹏 陈厚早 万言珍 张然 张祝琴 杨瑞锋 王旭 徐静 刘德培 
国家自然科学基金(批准号:31271227;31028005;31021091);国家重点基础研究发展计划(批准号:2011CB503902;2012BAI39B03)资助项目
白细胞在内皮中的富集能够引起炎症并触发动脉粥样硬化,intercellular adhesion molecule-1(ICAM-1)在该过程中发挥了重要作用.本实验室先前研究显示,内皮特异过表达Ⅲ类组蛋白去乙酰化酶SIRT1能够抑制动脉粥样硬化.因此,提出这样的假设...
关键词：SIRT1 ICAM-1 PMA和ionomycin 
SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells被引量：10
《Science China(Life Sciences)》2013年第1期19-25,共7页JIA YuYan GAO Peng CHEN HouZao WAN YanZhen ZHANG Ran ZHANG ZhuQin YANG RuiFeng WANG Xu XU Jing LIU DePei 
supported by National Natural Science Foundation of China(31271227,31028005,31021091);National Basic Research Program of China (2011CB503902,2012BAI39B03)
Intercellular adhesion molecule-1 （ICAM-1） plays an important role in the recruitment of leukocytes to the endothelium, which causes inflammation and initiation of atherosclerosis. We have previously shown that endo...
关键词：SIRT1 ICAM-1 PMA and ionomycin 
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