国家重点基础研究发展计划(2010CB945600)

作品数:9被引量:129H指数:5
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相关作者:陈费胡以平何志颖金圣博景秋洋更多>>
相关机构:第二军医大学同济大学泸州医学院上海交通大学更多>>
相关期刊:《生命的化学》《上海交通大学学报(医学版)》《Science China(Life Sciences)》《Chinese Medical Journal》更多>>
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Microarray Analysis of Gene Expression Changes in Neuroplastin 65-Knockout Mice: Implications for Abnormal Cognition and Emotional Disorders被引量:5
《Neuroscience Bulletin》2018年第5期779-788,共10页Huanhuan Li Jiujiang Zeng Liang Huang Dandan Wu Lifen Liu Yutong Liu Qionglan Yuan 
supported by the National Natural Science Foundation of China(81371213,81070987,and30971531);the grants from the Ministry of Science and Technology of China(2010CB945600 and 2010CB945601)
Neuroplastin 65 (Np65) is an immunoglobulin superfamily cell adhesion molecule involved in synaptic formation and plasticity. Our recent study showed that Np65-knockout (KO) mice exhibit abnormal cognition and emo...
关键词:Neuroplastin 65 Microarray analysis Gene expression profile Htr3a WNT 
HDAC1基因决定涡虫成体干细胞的维持被引量:1
《上海交通大学学报(医学版)》2013年第9期1202-1208,共7页张振超 曾安 韩晓帅 李永芹 荆清 
国家自然科学基金重点项目(81130005);国家重点基础研究发展计划(2010CB945600)~~
目的分析涡虫HDAC1基因的表达谱,并研究HDAC1基因在涡虫稳态维持和再生中的功能及机制。方法利用cDNA末端快速扩增技术获得涡虫HDAC1基因的全长序列,利用全组织原位杂交技术和Western blotting技术分别检测HDAC1转录本和蛋白在涡虫中的...
关键词:涡虫 再生 HDAC1 成体干细胞 
构建稳定表达胞外信号调节激酶的大鼠骨髓间充质干细胞及其对大鼠脑卒中的神经保护作用被引量:2
《解剖学杂志》2013年第3期345-349,360,共6页王戈鹰 窦玲 吴爽 张海波 张毅杰 曾嘉齐 杨朝鲜 黄良 袁琼兰 
科技部973基金(2010CB945600,2011CB965100);国家自然科学基金(81070987,30971531);2012年全国大学生科技创新项目
目的:构建稳定表达细胞外信号调节激酶(ERK1/2)的骨髓间充质干细胞(MSCs)及探讨其对脑卒中的神经保护作用。方法:制备ERK1/2重组病毒和空病毒(对照),并转染大鼠MSCs,分别构建ERK1/2/MSCs和BV/MSCs(对照)。用RT-PCR和...
关键词:胞外信号调节激酶 慢病毒载体 骨髓间充质干细胞 转染 脑卒中 神经保护 
Transplantation of neural stem cells overexpressing glial cell line-derived neurotrophic factor enhances Akt and Erkl/2 signaling and neurogenesis in rats after stroke被引量:9
《Chinese Medical Journal》2013年第7期1302-1309,共8页YUAN Miao WEN Sheng-jun YANG Chao-xian PANG Yuan-guang GAO Xiao-qing LIU Xiao-qing HUANG Liang YUAN Qiong-lan 
This study was supported by grants from State Key Laboratory of Medical Neurobiology, Fudan University, and the programs from the Ministry of Science and Technology of China (No. 2010CB945600 and No. 2011CB965100), the National Natural Science Foundation of China (No. 81070987, No. 30971531), Shanghai Science Foundation (No. 11PJ1407800), and National Education Ministry (IRT1168), International Science & Technology Collaboration Program (No. 2011DF30010).
Background Our previous studies have indicated that the beneficial effects of grafting neural stem cells (NSCs) overexpressing glial cell line-derived neurotrophic factor (GDNF) in rats after stroke. However, the ...
关键词:glial cell line-derived neurotrophic factor neural stem cells TRANSPLANTATION NEUROGENESIS 4kt and Erkl/2 signaling 
细胞直接重编程:从一种终末分化细胞直接重编程为另一种终末分化细胞被引量:2
《生命的化学》2012年第4期299-304,共6页景秋洋 陈费 金圣博 何志颖 胡以平 
国家973计划(2010CB945600);国家自然科学基金项目(30801115);国家社会科学基金教育学青年课题(CIA090114)资助
细胞的直接重编程是指将一种终末分化细胞直接转变为另一种终末分化细胞,这一转变不经过诱导多能干细胞阶段和去分化、再分化等过程。最近的一系列研究结果已经证明了这一研究方法的可行性,这些研究进展不仅为重编程的分子机制研究提供...
关键词:直接重编程 诱导性多能干细胞 细胞治疗 
Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells被引量:28
《Cell Research》2012年第1期219-236,共18页Nan Cao Zumei Liu Zhongyan Chen Jia Wang Taotao Chen Xiaoyang Zhao Yu Ma Lianju Qin Jiuhong Kang Bin Wei Liu Wang Ying Jin Huang-Tian Yang 
This study was supported by grants from the National Basic Research Program of China (2011 CB965300, 2009CB941100, 2010CB945600), the National Natural Science Foundation of China (31030050), Strategic Priority Research Program of CAS (XDA01000000), Science and Technology Committee of Shanghai Municipality (08DJ1400501), National Science and Technology Project of China (2012ZX09501-001-001), and Sanofi-Aventis Re- cherche & D6veloppement-SIBS funding. We thank Dr Duanqing Pei (Guangzhou Institutes of Biomedicine and Health, China) for kindly providing the miPSC lines iPS-C5 and iPS-C12.
Generation of induced pluripotent stem cells (iPSCs) has opened new avenues for the investigation of heart diseases, drug screening and potential autologous cardiac regeneration. However, their application is hamper...
关键词:induced pluripotent stem cells ascorbic acid CARDIOMYOCYTES cardiac progenitor cells 
肝脏发育相关信号通路
《生命的化学》2011年第4期545-551,共7页陈费 王敏君 向导 刘长城 何志颖 王欣 胡以平 
国家"973"计划(2010CB945600);国家自然科学基金项目(30801115)资助
肝脏发育从肝芽的出现开始,到肝祖细胞的形成,接着肝祖细胞的增殖、分化和迁移,直至最后器官的形成,经历了复杂的细胞信号调控过程。本文综述了肝脏发育过程中常见的信号调控作用,包括成纤维生长因子(fibroblast growth factor,FGF)、...
关键词:肝脏发育 信号通路 肝细胞 肝再生 
Xeno-repopulation of Fah^(-/-)Nod/Scid mice livers by human hepatocytes被引量:6
《Science China(Life Sciences)》2011年第3期227-234,共8页SU BaoLiang LIU ChangCheng XIANG Dao ZHANG HaiBin YUAN SiMing WANG MinJun CHEN Fei ZHU HaiYing HE ZhiYing WANG Xin HU YiPing 
supported by the National High Technology Research and Development Program of China(Grant No. 2006AA02Z474);the National Natural Science Foundation of China(Grant No. 30801115);the China Postdoctoral Science Foundation(Grant No. 20070410743);the National Basic Research Program of China(Grant No. 2010CB945600)
Functional human hepatocytes xenografted into the liver of mice can be used as a model system to study pharmacokinetics,infection of hepatitis viruses,and the efficacy of hepatitis vaccines.Significant levels of liver...
关键词:human hepatocyte humanized liver cell transplantation Fah gene knockout mice Nod/Scid mice 
Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair被引量:76
《Cell Research》2010年第5期510-518,共9页Yufang Shi Gangzheng Hu Juanjuan Su Wenzhao Li Qing Chen Peishun Shou Chunliang Xu Xiaodong Chen Yin Huang Zhexin Zhu Xin Huang Xiaoyan Han Ningxia Xie Guangwen Ren 
Mesenchymal stem cells (MSCs) have great potential for treating various diseases, especially those related to tissue damage involving immune reactions. Various studies have demonstrated that MSCs are strongly immuno...
关键词:MSCS IMMUNOSUPPRESSION tissue repair immune diseases 
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