云南高校图书馆联盟文献共享服务平台- 国家自然科学基金(81121004)

国家自然科学基金(81121004): 作品数：33被引量：164H指数：6; 导出分析报告; 相关作者：姚咏明付小兵张翠萍祝筱梅张庆红更多>>; 相关机构：解放军总医院第一附属医院中国人民解放军总医院第一附属医院中国人民解放军总医院天津医科大学更多>>; 相关期刊：《Science China(Life Sciences)》《Signal Transduction and Targeted Therapy》《中华消化外科杂志》《国际外科学杂志》更多>>; 相关主题：IN_CHINASTEM_CELLTISSUE_ENGINEERINGMICROENVIRONMENT高迁移率族蛋白B1更多>>; 相关领域：医药卫生生物学环境科学与工程自动化与计算机技术更多>>

成簇规律间隔短回文重复序列及其相关蛋白基因9系统在干细胞研究中的应用进展: 《中华烧伤杂志》2018年第4期253-256,共4页孙苏静霍嘉慧耿志军孙晓艳付小兵; 国家自然科学基金（81121004、81230041、81421064、81372067）; 随着对DNA碱基精确识别的核酸酶研究的深入，第3代基因编辑技术，如锌指核酸酶（ZFN）技术、类转录激活因子样效应物核酸酶（TALEN）技术等发展迅速，由于该类技术能够精确地进行DNA水平的特定位点敲除、插入及替换，加深研究者对生物...; 关键词：干细胞成簇规律间隔短回文重复序列及其相关蛋白基因9 基因编辑

上皮-间质转化在皮肤创面修复中作用的研究进展: 《中华创伤杂志》2017年第10期949-953,共5页霍嘉慧孙苏静耿志军李想孙晓艳马奎付小兵; 国家自然科学基金（30901564,81101883,81245185,81372067,81121004,81230041）;国家重点基础研究发展计划（“973”计划）（2012CB518105）; 上皮一间质转化（ epithelial - mesenchymal transition，EMT）最早的描述见于19世纪60年代Trelstad等。发现在鸡胚胎形成过程中，单胚层重组为三层结构，此过程也被称为原肠胚形成。随后，Greenburg和Hay提出了EMT的概念，即上皮细胞...; 关键词：上皮-间质转化创面修复皮肤器官纤维化 EMT 胚胎形成三层结构细胞极性

3D生物打印的微结构促进小鼠表皮干细胞的增殖和活性被引量：6: 《南方医科大学学报》2017年第6期761-766,共6页刘煜凡黄沙姚斌李曌李想付小兵吴旭; 国家重点基础研究发展计划“973计划”(2012CB518105);国家自然科学基金(81121004,81671905)~~; 目的探索不同构架的3D微结构对表皮干细胞增殖能力和细胞活性的影响并建立最佳3D生物打印模型。方法通过采用不同尺寸:210、340、420μm的打印喷头结合3D生物打印技术构建3种不同的含细胞3D微结构;利用荧光显微镜观察3D微结构中细胞形...; 关键词：3D生物打印技术 3D微结构表皮干细胞细胞增殖细胞活性

Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation被引量：28: 《Science China(Life Sciences)》2016年第12期1305-1312,共8页Dongdong Ti Haojie Hao Xiaobing Fu Weidong Han; supported by the National Basic Science and Development Program(2012CB518103,2012CB518105);National High Technology Research and Development Program of China (2013AA020105,2012AA020502);National Natural Science Foundation of China(81121004,81501682,81230041); Clinical and experimental studies have highlighted the significance of inflammation in coordinating wound repair and regeneration.However,it remains challenging to control the inflammatory response and tolerance at sy...; 关键词：microRNA INFLAMMATION mesenchymal stem cell EXOSOME

Dynamic microenvironment and multiple damaged tissue regeneration in a de novo and synchronized manner: 《Science China(Life Sciences)》2016年第12期1332-1334,共3页Biao Cheng Xiaobing Fu; supported in part by the National Nature Science Foundation of China (81121004, 81230041, 81171798, 81171812, 81272105, 81671924);the National Basic Science and Development Programme (2012CB518105);the National Science and Technology Major Project (2011ZXJ07104B-03B); Regenerative medicine has rapidly developed over the past decade and created new opportunities to repair or replace tissue or organ function lost because of congenital defects, age, diseases, or serious damage （Cheng...; 关键词：CELL Dynamic microenvironment and multiple damaged tissue regeneration in a de novo and synchronized manner

Skin appendage-derived stem cells: cell biology and potential for wound repair被引量：3: 《Burns & Trauma》2016年第4期258-263,共6页Jiangfan Xie Bin Yao Yutong Han Sha Huang Xiaobing Fu; This paper was supported in part by the National Nature Science Foundation of China(81121004,81230041,81372066,81571909);the National Basic Science and Development Program(973 Program,2012CB518105); Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration.These stem cells also participate in the repair of the epidermis after injuries,inducing restoration of tis...; 关键词：Skin appendages Stem cells Cell biology Wound healing

Innovative and propagable translational research model established for cell-based therapy at Chinese PLA General Hospital被引量：1: 《Science China(Life Sciences)》2016年第10期1063-1067,共5页Weidong Han Xiaobing Fu; supported by the National Natural Science Foundation of China(81230061,81121004,and 81230041);the Military Medical Foundation(AWS11J008);the National Basic Research Program of China(2012CB518105); The use of translational medicine in Chinese hospitals ap- pears to have become easier over the last decade. Products developed in the laboratory can sometimes be applied in the clinic under life-saving circumstances....; 关键词：中国人民解放军细胞疗法转化医院模型创新实验室应用

Regenerative medicine in China:demands, capacity,and regulation被引量：2: 《Burns & Trauma》2016年第2期71-77,共7页Biao Cheng Shuliang Lu Xiaobing Fu; This study was supported in part by the National Nature Science Foundation of China(81121004,81230041,81171812,81272105,and 81171798);the National Basic Science and Development Programme(973 Program,2012CB518105);National Science and Technology Major Project(2011ZXJ07104B-03B); Regenerative medicine(RM)is an emerging interdisciplinary field of research.Its clinical application focuses on the repair,replacement,and regeneration of cells,tissues,and organs by approaches including cell reprogra...; 关键词：Regenerative medicine Stem cell Tissue engineering China

Regenerative medicine in China:main progress in different fields被引量：5: 《Journal of Medical Colleges of PLA(China)》2016年第3期140-152,共13页Biao Cheng Shu-Liang Lu Xiao-Bing Fu; supported by the National Nature Science Foundation of China(81171812,81272105,81121004,81230041,and 81171798);the National Basic Science and Development Programme(973 Programme,2012CB518105);the National Science and Technology Major Project(2011ZXJ07104B-03B);the Health and Medical Treatment Collaborative Innovation Major Special Projects of Guangzhou(No.201508020253);the Science and Technology Key Project of Guangdong Province(2014B020212010); Regenerative medicine(RM) is an emerging interdisciplinary field of research and China has developed the research quickly and impressed the world with numerous research findings in stem cells,tissue engineering,active...; 关键词：Regenerative medicine Stem cells Tissue engineering China

不同时期小鼠汗腺细胞的培养及角蛋白表达: 《中华实验外科杂志》2016年第2期338-341,共4页谢江帆黄沙付小兵; 国家重点基础研究发展计划（973计划）资助项目（2012CB518105）;国家自然科学基金（81121004、81372066）; 目的阐明不同时期小鼠汗腺细胞的形态学变化及角蛋白（K）表达特征。方法通过分离培养小鼠汗腺原代细胞，观察其形态学变化，免疫荧光法检测角蛋白表达特征。结果出生后（P）0．5d到出生后28．0d（P28）汗腺卷曲成团并出现导管部和分泌...; 关键词：汗腺细胞的分离培养细胞角蛋白的表达汗腺再生

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