云南高校图书馆联盟文献共享服务平台- 国家自然科学基金(30370798)

国家自然科学基金(30370798): 作品数：13被引量：23H指数：3; 导出分析报告; 相关作者：李霞郭政朱晶张敏朱明珠更多>>; 相关机构：哈尔滨医科大学首都医科大学同济大学电子科技大学更多>>; 相关期刊：《高技术通讯》《遗传》《Science Bulletin》《Progress in Natural Science:Materials International》更多>>; 相关主题：基因表达谱GENEDECISIONTREE特征基因更多>>; 相关领域：生物学医药卫生自动化与计算机技术农业科学更多>>

Mining Functional Gene Modules Linked with Rheumatoid Arthritis Using a SNP-SNP Network被引量：2: 《Genomics, Proteomics & Bioinformatics》2012年第1期23-34,共12页Lin Hua Hui Lin Dongguo Li Lin Li Zhicheng Liu; supported in part by the National Natural Science Foundation of China (Grant No. 30871394, 30370798 and 30571034);the Science Technology Development Projects of Beijing Municipal Education Commission (KM200910025006 and KM201210025008); The identification of functional gene modules that are derived from integration of information from different types of networks is a powerful strategy for interpreting the etiology of complex diseases such as rheumato...; 关键词：polymorphism interaction analysis hub SNP sub-networks GO enrichment analysis

Mapping and characterization of two relevance networks from SNP and gene levels: 《Progress in Natural Science:Materials International》2009年第5期653-657,共5页Wei Jiang a,1, Lijie Zhang b,1, Bo Na a, Lihong Wanga, Jiankai Xu a, Xia Li a,b,c, Yadong Wangb, Shaoqi Rao da College of Bioinformatics Science and Technology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, China b Department of Mathematics and Computer Science, Harbin Institute of Technology, Harbin 150080, China c Department of Bioinformatics, Capital University of Medical Sciences, Beijing 100084, China d Department of Cardiovascular Medicine and Molecular Cardiology, The Cleveland Clinic Foundation, 9600 Euclid Avenue, Cleveland, OH 44195, USA; supported by the National Natural Science Foundation of China (Grant Nos. 30370798,30571034 and 30570424);the National Hi-Tech Research and Development Program of China (Grant No.2007AA02Z329);the National Program on Key Basic Research Projects (Grant No. 2008CB517302); Variations of gene expression and DNA sequence are genetically associated. The goal of this study was to build genetic networks to map from SNPs to gene expressions and to characterize the two different kinds of netwo...; 关键词：SNP relevance network Gene relevance network Network mapping Network topology

Identifying drug-target proteins based on network features被引量：3: 《Science China(Life Sciences)》2009年第4期398-404,共7页ZHU MingZhu1, GAO Lei1, LI Xia1,2 & LIU ZhiCheng1 1 School of Biomedical Engineering, Capital Medical University, Beijing 100069, China 2 College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China; Supported by National Natural Science Foundation of China (Grant No. 30370798, 30571034 and 30570424);National High-Tech Research and Development Program of China (Grant No. 2007AA02Z329);National Basic Research Program of China (Grant No. 2008CB517302); Natural Science Foundation of Heilongjiang Province, China (Grant No. ZJG0501, 1055HG009, GB03C602-4 and BMFH060044); New Century Hundred-Thousand-Ten Thousand Talents Project of Beijing City, Scientific Research Common Program of Beijing Municipal Commission of Education (KM200610025011).; Proteins rarely function in isolation inside and outside cells, but operate as part of a highly intercon- nected cellular network called the interaction network. Therefore, the analysis of the properties of drug-targe...; 关键词：drug-target PROTEIN-PROTEIN INTERACTION TOPOLOGICAL FEATURES

结合蛋白质互作与功能类的可分性预测蛋白质功能: 《中国生物医学工程学报》2009年第2期270-274,共5页朱明珠高磊李彦辉马文才朱晶张敏郭政李霞; 国家自然科学基金资助项目(30571034,30370798,30570424,30600367);2006年北京市新世纪百千万人才工程;北京市教育委员会科技发展计划资助项目(KM200610025011); 当前蛋白质功能注释体系的欠完备性限制了生物学及医药研究的进一步发展和应用,有必要将基因本体功能知识体系(GO)的功能注释信息进一步深化,把蛋白质注释到GO中更具体的功能节点。为此,提出一种结合互作信息的新的预测策略,将酵母蛋白...; 关键词：蛋白质功能深化预测基因本体功能知识体系(GO) 预测空间

Cell cycle-dependent gene networks relevant to cancer: 《Progress in Natural Science:Materials International》2008年第8期945-952,共8页Yun Xiao Xia Li Yueying Yang Yadong Wang Shaoqi Rao; the National High-Tech Development Project of China (Grant No.2007AA02Z329);National Natural Science Foundation of China (Grant Nos. 30170515, 30370798, 30571034,30570424 and 60601010);Outstanding Overseas Scientist Grant of the Heilongjiang Province (Grant No.1055HG009);National Science Foundation of Heilongjiang Province (Grant Nos. ZJG0501, GB03C602-4 and F2004-02);Health Department of Heilongjiang Province Key Project (2005-39).; The analysis of sophisticated interplays between cell cycle-dependent genes in a disease condition is one of the largely unexplored areas in modern tumor biology research. Many cell cycle-dependent genes are either on...; 关键词：Cell cycle MICROARRAY HeLa cell Gene network

基于网络特征的药物靶蛋白识别被引量：1: 《中国科学（C辑）》2008年第12期1184-1190,共7页朱明珠高磊李霞刘志成; 国家高技术研究发展计划(批准号:2007AA02Z329);国家自然科学基金(批准号:30571034,30370798,30570424和30600367);北京市新世纪百千万人才工程、北京市教育委员会科技发展计划(批准号:KM200610025011)资助项目; 蛋白质很少孤立得发挥作用,往往通过网络中彼此互作来共同行使功能.因此分析药物靶蛋白在生物学网络中的性质将十分有助于从信息学角度理解药物的作用机制.但目前尚无研究对药物靶蛋白在人类蛋白质互作网络中的拓扑特性给与具体的分析...; 关键词：药物靶点蛋白质互作拓扑特征

离子通道亚型与其基因共表达的关联研究: 《遗传》2008年第9期1157-1162,共6页杨德武李霞肖雪杨月莹王靖; 国家自然科学基金(编号:30571034, 30370798);国家高技术研究发展计划项目(863 项目) (编号:2007AA02Z329);2006年北京市新世纪百千万人才工程,北京市教育委员会科技发展计划项目(编号:KM200610025011)资助~~; 离子通道亚型与其基因共表达的关联对研究离子通道功能有重要意义。文章采用主成分分析和模糊C-均值聚类算法对数据进行分析,将方法应用到人类和小鼠两套表达谱数据,结果发现离子通道亚型中钾离子通道、钙离子通道、氯离子通道和受体激...; 关键词：离子通道基因表达谱离子通道亚型共表达关联

Widely predicting specific protein functions based on protein-protein interaction data and gene expression profile被引量：3: 《Science China(Life Sciences)》2007年第1期125-134,共10页GAO Lei1, LI Xia1,2, GUO Zheng1,2, ZHU MingZhu1, LI YanHui1 & RAO ShaoQi1,3 1 Department of Bioinformatics, Harbin Medical University, Harbin 150086, China 2 School of Biology Science and Technology, Tongji University, Shanghai 200092, China 3 Departments of Molecular Cardiology and Cardiovascular Medicine, the Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleve-land, Ohio 44195, USA; the National Natural Science Foundation of China (Grant Nos. 30170515, 30370388, 30370798, 30570424 and 30571034),;the National High Tech Development Project of China (Grant Nos. 2003AA2Z2051 and 2002AA2Z2052),;Heilongjiang Science & Technology Key Project (Grant No. GB03C602-4),;Harbin (City) Science & Technology Key Project (Grant No. 2003AA3CS113),;Natural Science Foundation of Heilongjiang (Grant No. F0177 ),;Outstanding Overseas Scientist Foundation of Education Department of Heilongjiang Province (Grant No. 1055HG009); GESTs (gene expression similarity and taxonomy similarity), a gene functional prediction approach previously proposed by us, is based on gene expression similarity and concept similarity of functional classes defined ...; 关键词：GENE expression profile PROTEIN-PROTEIN interaction GENE ONTOLOGY SIMILARITY GENE function prediction

Identifying disease feature genes based on cellular localized gene functional modules and regulation networks被引量：3: 《Chinese Science Bulletin》2006年第15期1848-1856,共9页ZHANG Min ZHU Jing GUO Zheng LI Xia YANG Da WANG Lei RAO Shaoqi; supported in part by the National Natural Science Foundation of China(Grant Nos.30170515,30370388,30370798,30570424&30571034);the National High Tech Development Project of China(Grant Nos.2003AA2Z2051&2002AA2Z2052);Heilongjiang Science&Technology Key Project(Grant No.GB03C602-4);Harbin(City)Science&Technology Key Project(Grant No.2003AA3CS113);the Natural Science Foundation of Heilongjiang Province(Grant No.F0177);0utstanding 0verseas Scientist Foundation of Education Department of Heilongjiang Province(Grant No.1055HG009).; Identifying disease-relevant genes and functional modules, based on gene expression pro- files and gene functional knowledge, is of high im- portance for studying disease mechanisms and sub- typing disease phenotypes....; 关键词：基因表达基因序列特征基因基因复制

利用亚细胞位置特异的基因功能模块与表达调控网络识别疾病特征基因被引量：3: 《科学通报》2006年第13期1545-1551,共7页张敏朱晶郭政李霞杨达王磊饶绍奇; 国家自然科学基金（批准号：30170515,30370388,30370798,30570424,30571034）;国家重点基础研究发展计划（批准号：2003AA2Z2051,2002AA2Z2052）;黑龙江科技攻关重点（批准号：GB03C602-4）;哈尔滨市科技攻关（批准号：2003AA3CS113）;黑龙江自然科学基金（批准号：F0177）;黑龙江省教育厅杰出海外学人基金（批准号：1055HG009）资助项目.; 利用GeneOntology中的生物过程(biologicalprocess)及细胞组分(cellularcomponent)两种分类体系,选择显著聚集差异表达基因的复合功能模块,识别其中能够有效分类疾病样本的特征功能模块,以特征功能模块中的差异表达基因作为特征并分析...; 关键词：基因表达谱 Gene Ontology 功能模块特征基因基因调控网络

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