国家自然科学基金(20872019)

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相关期刊：《Chinese Journal of Chemistry》《Science China Chemistry》更多>>
相关主题：LEWIS_ACIDINHIBITORSALKALOIDSAGAINSTSYNTHESIS更多>>
相关领域：轻工技术与工程生物学理学更多>>
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Synthesis and Evaluation of the Analogues of Penicillide against Cholesterol Ester Transfer Protein
《Chinese Journal of Chemistry》2013年第3期355-370,共16页Qiao Zhang Chunlin Deng Lisong Fang Wenwei Xu Qun Zhao Jiange Zhang Yiping Wang Xinsheng Lei 
We thank the National Natural Science Foundation of China （20872019） for the research financial support and we are grateful to Fudan University and Shanghai Institute of Organic Chemistry for recording EI-MS or ESI-MS, HRMS, ^1H NMR, and ^13C NMR spectra. We are also grateful to Dr. Hanqing Dong （OSI Pharma-ceuticals, USA） for his help in revising the manuscript.
A series ofpenicillide analogues, with modifications at C-3 and C-9 positions, are synthesized as potential cho-lesteryl ester transfer protein （CETP） inhibitors. The preliminary in vitro inhibition assay provided s...
关键词：CROSS-COUPLING LACTONE INHIBITORS cholesterol ester transfer protein penicillide 
Regio-selective chlorination of vinca alkaloids catalyzed by Lewis acid
《Science China Chemistry》2011年第7期1039-1043,共5页FANG LiSong ZHANG Qiao DENG ChunLin LEI XinSheng LIN GuoQiang 
the National Natural Science Foundation of China (20872019);Fudan University for the research financial support
Novel C-17-chloro-substituted derivative of vinorelbine or vinflunine has been regio-selectively synthesized via the chlorination reaction in the presence of Lewis acid.The catalyst Cp2TiCl2 plays a key role in the ch...
关键词：ALKALOIDS HALOGENATION REGIO-SELECTIVITY SUBSTITUTION Lewis acids 
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