Projrct supportted by the National Natural Science Foundation of China (Nos. 20772144, 20825209, 20832008) and the Chinese Academy of Sciences (Hundreds-Talent Program and Knowledge Innovation Program).
Difluoromethyltri(n-butyl)ammonium chloride 1 was found to be an effective difluorocarbene reagent for O-, S-, N-, C-difluoromethylation under basic conditions. It is particularly remarkable that, when only 1.2 equi...