国家自然科学基金(30125038)

作品数:7被引量:32H指数:4
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相关作者:吴学忠田志刚魏海明金腾川郑晓东更多>>
相关机构:中国科学技术大学山东省皮肤病医院更多>>
相关期刊:《Cellular & Molecular Immunology》《中国麻风皮肤病杂志》《细胞与分子免疫学杂志》《Cell Research》更多>>
相关主题:AG85BPROLACTINC57BL/6B16细胞DO更多>>
相关领域:医药卫生生物学更多>>
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Ag85B诱发抗肿瘤免疫效应
《中国麻风皮肤病杂志》2007年第1期10-11,共2页吴学忠 魏海明 金腾川 田志刚 
国家自然科学基金杰出青年基金项目(30125038);国家重点基础研究发展计划项目(2001CB510009)
目的:探讨Ag85B在荷瘤小鼠体内诱发抗肿瘤免疫效应。方法:C57BL/6小鼠静脉接种B16细胞,8 d后于对照组和实验组分别输入经照射的B16/pcDNA3细胞和B16/pcDNA3-Ag85B细胞,观测肿瘤结节和体积。结果:对照组小鼠在第18 d肺部开始出现2个肿瘤...
关键词:B16/pcDNA3 B16/pcDNA3-Ag85B C57BL/6 抗肿瘤免疫 
结核杆菌抗原Ag85B诱导抗黑素瘤免疫应答及其机制研究被引量:1
《细胞与分子免疫学杂志》2007年第1期36-38,共3页吴学忠 魏海明 郑晓东 金腾川 田志刚 
国家自然科学基金杰出青年基金项目(30125038);国家重点基础研究发展规划(973)资助项目(2001CB510009)
目的:探讨Ag85B在诱发抗黑素瘤免疫应答中的作用,以及其用于肿瘤免疫治疗的可行性。方法:经背部皮下接种黑色素瘤细胞株B16建立C57BL/6小鼠荷瘤模型,并分为对照1、2组和实验组。于荷瘤模型建立后,对照1、2组经背部皮下分别接种B16细胞和...
关键词:pcDNA3-Ag85B B16细胞 C57BL/6 肿瘤免疫 
The Involvement of Heat Shock Proteins in Murine Liver Regeneration被引量:10
《Cellular & Molecular Immunology》2007年第1期53-57,共5页Qing Shi Zhongjun Dong Haiming Wei 
This work was supported by National Natural Science Foundation of China (#30125038, #30230340);National 973 Basic Science Program (#2001CB510009, #2003CB515501);Foundation of Chinese Academy of Science (#KSCX2-2-08).
Partial hepatectomy (PHx) in mammals is a very common experimental model to investigate the process of liver regeneration. The surgery itself could give birth to a series of stresses, such as the temporary raise of ...
关键词:partial hepatectomy liver regeneration heat shock protein 
Ag85B真核表达载体的构建及其生物活性的研究
《中国麻风皮肤病杂志》2006年第10期800-803,共4页吴学忠 魏海明 刘文涛 张小俊 田志刚 
国家自然科学基金杰出青年基金项目(30125038);国家重点基础研究发展计划项目(2001CB510009)
目的:研究Ag85B蛋白促PPD+人外周血单个核细胞的增殖活性。方法:用PCR技术扩增Ag85B基因,构建重组pcDNA3-Ag85B,并将其转染B16细胞株,用RT-PCR鉴定阳性细胞克隆,用Westernblotting鉴定其在阳性细胞克隆内的表达,用3H-TdR掺入法来检测Ag...
关键词:AG85B PCDNA3 B16细胞 增殖活性 
The Regulatory Effect of Natural Killer Cells:Do "NK-reg Cells" Exist?被引量:15
《Cellular & Molecular Immunology》2006年第4期241-254,共14页Cai Zhang Jian Zhang Zhigang Tian 
supported by Natural Science Foundation of China(#30125038,#30230340,#30371302);National 973 Program(#2001CB510009);Science Foundation of Shandong Province(#Y2002C24,#2005BS03015).
The most important progress in immunology in the last decade is the description of regulatory lymphocytes, among which Treg cells and regulatory NKT cells are much attractive to not only immunologists but also almost ...
关键词:natural killer cell regulatory T cell innate immunity immune regulation 
Human Prolactin Improves Engraftment and Reconstitution of Human Peripheral Blood Lymphocytes in SCID Mice被引量:4
《Cellular & Molecular Immunology》2004年第2期129-136,共8页RuiSun JianZhang CaiZhang JianhuaZhang ShujuanLiang AnyuanSun JunfuWang ZhigangTian 
supported by 0utstanding Young Scientist Award and Key Project by Natural Science Foundation of China(#30125038,#30230340);Key Basic Science Program by Ministry of Science and Technology of China(#2001CB510009);Foundation of Chinese Academy of Science(#KSCX2-2-08).
Recombinant human prolactin(rhPRL)was administered to huPBL-SCID mice to determine its effects on human immunologic reconstitution and function.The huPBL-SCID mice were given 10 μg i.p.injection of rhPRL every other ...
关键词:human/mouse chimera PROLACTIN B cell T cell 
Expression of prolactin receptor and response to prolactin stimulation of human NK cell lines被引量:4
《Cell Research》2004年第1期67-73,共7页RuiSUN AiLingLI HaiMingWEI ZhiGangTIAN 
supported partly by Outstanding Young Scientist Award and Key Project by Natural Science Foundation of China(No.30125038,No.30230340);The Major Sate Basic research Development program of China(No.2001CB510009);The National high technology research and Development program of China(No.2002AA216151)by Ministry of Science and Technology of China;Key Project by Chinese Academy of Science(No.KSCX2-2-08).
We have previously shown a critical role of prolactin (PRL) during maturation and anti-tumor effects of murine natural killer (NK) cells in vitro and in vivo. We extended that study by exploring the ability of human N...
关键词:prolactin receptor NK cell INTERLEUKIN-2 interleukin-15. 
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