Acknowledgements Dr Shu WANG (Ruijin Hospital of Shanghai Jiao Tong Uni- versity, Shanghai, China) assisted with the delivery of the adenovirus. This work was supported through the National Natural Science Foundation of China (30901461, 81070625 and 81101590), the Natural Science Foundation of Shandong Province (2009CM005 and BS2010YY049) and the Ji-nan Self- renovation Plan for Colleges and Universities and Scientific Research Institutes (200906012) of China.
Aim: To investigate the effects of diosgenin (Dio), a naturally occurring steroid saponin, on goiter formation in a mouse model of Graves’ disease (GD) and the underlying mechanisms. Methods: Female BALB/c mice...