国家自然科学基金(11274374)

作品数：5被引量：1H指数：1
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单分子荧光共振能量转移数据处理的优化算法
《物理学报》2017年第11期339-346,共8页吕袭明 李辉 尤菁 李伟 王鹏业 李明 奚绪光 窦硕星 
国家自然科学基金(批准号:11674383,11474346,11274374);国家重点基础研究发展计划(批准号:2013CB837200);国家重点研究发展计划(批准号:2016YFA0301500)资助的课题~~
单分子荧光共振能量转移(smFRET)技术是当今单分子生物物理研究领域的重要实验手段,该技术通过测量供体、受体荧光光强以及二者间的共振能量转移效率,揭示标记位点间的距离,用于研究DNA、蛋白质等生物大分子的构象变化.然而,当前传统数...
关键词：单分子荧光共振能量转移 数据处理算法 G-四联体DNA 折叠动力学 
Helicase activity and substrate specificity of RecQ5β
《Chinese Physics B》2017年第6期499-507,共9页尤菁 徐雅楠 李辉 吕袭明 李伟 王鹏业 窦硕星 奚绪光 
supported by the National Natural Science Foundation of China(Grant Nos.11674383,11474346,and 11274374);the National Basic Research Program of China(Grant No.2013CB837200);the National Key Research and Development Program of China(Grant No.2016YFA0301500)
RecQ5β is an essential DNA helicase in humans, playing important roles in DNA replication, repair, recombination and transcription. The unwinding activity and substrate specificity of RecQ5β is still elusive. Here, ...
关键词：HELICASE RecQ5β DNA substrate specificity unwinding kinetics 
Brownian ratchet mechanism of translocation in T7 RNA polymerase facilitated by a post-translocation energy bias arising from the conformational change of the enzyme
《Chinese Physics B》2017年第3期195-206,共12页王展峰 张志强 付一本 王鹏业 谢平 
Project supported by the National Natural Science Foundation of China(Grant Nos.11374352 and 11274374);the National Key Research and Development Program of China(Grant No.2016YFA0301500)
T7 RNA polymerase can transcribe DNA to RNA by translocating along the DNA. Structural studies suggest that the pivoting rotation of the O helix in the fingers domain may drive the movement of the O helix C-terminal T...
关键词：RNA polymerase molecular dynamics simulation molecular motor Brownian ratchet 
Local conformation transitions of linear DNA induced by cisplatin被引量：1
《Chinese Science Bulletin》2014年第25期3085-3089,共5页Chao Ji Lingyun Zhang Shuoxing Dou Pengye Wang 
supported by the National Natural Science Foundation of China(11274374);the National BasicResearch Program of China(2009CB930704)
Cisplatin is the most successful anti-tumor drug,and its pharmacological property is generally considered to derive from the modification of DNA molecules.Structural modifications of short DNA induced by cisplatin hav...
关键词：DNA分子 顺铂 诱导 构象转变 线性 结构改造 原子力显微镜 构象转换 
Effects of oxaliplatin on DNA condensation
《Science China(Physics,Mechanics & Astronomy)》2014年第11期2114-2120,共7页JU HaiPeng ZHANG HongYan LI Wei WANG PengYe 
supported by the National Natural Science Foundation of China(Grant Nos.11104341 and 11274374);the National Basic Research Program of China(Grant No.2013CB837200)
In this paper the interactions between DNA and anti-cancer drug oxaliplatin were investigated by using magnetic tweezers.The dynamics of DNA condensation due to oxaliplatin was traced under various forces.It is found ...
关键词：DNA condensation shortening torsion helpful constraint cisplatin analogues tethered traced 
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