HELICASE

作品数：52被引量：75H指数：4
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Interferon-αstimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
《Military Medical Research》2025年第2期184-203,共20页Kai-Wei Jia Ren-Qi Yao Yi-Wen Fan Ding-Ji Zhang Ye Zhou Min-Jun Wang Li-Yuan Zhang Yue Dong Zhi-Xuan Li Su-Yuan Wang Mu Wang Yun-Hui Li Lu-Xin Zhang Ting Lei Liang-Chen Gui Shan Lu Ying-Yun Yang Si-Xian Wang Yi-Zhi Yu Yong-Ming Yao Jin Hou 
National Key Research and Development Program of China(2023YFC2505900);National Natural Science Foundation of China(92269204,82171755,92369106,82171749,82171811,82073184);Military Outstanding Youth Program(2020QN06119,01-SWK JYCJJ07,23SWAQ53);Program of Leading Talents in Shanghai,and Shanghai Shuguang Program(20SG39)。
Background Liver ischemia/reperfusion(I/R)injury is usually caused by hepatic inflow occlusion during liver surgery,and is frequently observed during war wounds and trauma.Hepatocyte ferroptosis plays a critical role ...
关键词：Ischemia/reperfusion(I/R) DExH-box helicase 58(DHX58) Glutathione peroxidase 4(GPX4) m6A modification YT521-B homology domain containing 2(YTHDC2) 
DNA损伤应答中DEAD-box Helicase 41的潜在作用研究
《青岛大学学报(自然科学版)》2024年第4期8-12,18,共6页王心宇 朱敏 
国家自然科学基金(批准号:32201061)资助;山东省自然科学基金(批准号:ZR2021QC083)资助。
为探究死盒解旋酶41(DEAD-box Helicase 41,DDX41)的敲低如何影响DNA损伤应答(DNA Damage Repair,DDR),慢病毒筛选敲低DDX41(shDDX41)的HeLa细胞,转染质粒FLAG-USP11、GFP-DDX41至HEK-293T细胞,设置细胞空白对照组(NC细胞)和依托泊苷加...
关键词：DNA损伤应答 死盒解旋酶41 去泛素化酶 
Uncovering the Multifaceted Roles of DDX21:Bridging Biological Insights and Medical Applications
《Journal of Bio-X Research》2024年第3期119-133,共15页Jinze Shen Ruixiu Chen Kailin Guo Chenming Zhong Shiwei Duan 
supported by the Qiantang Scholars Fund at Hangzhou City University(no.210000-581835).
DDX21 belongs to the DEAD-box(DDX)family of helicases but deviates from the characteristic sequence Asp–Glu–Ala–Asp(DEAD)to Asp–Glu–Val–Asp.In addition to the typical helicase activity associated with the DEAD-b...
关键词：transcription regulation foldase DDX molecular processesincluding adenosine triphosphatase DEAD box helicase ribosomal RNA processing 
DEAD-box helicase 17(DDX17)protects cardiac function by promoting mitochondrial homeostasis in heart failure
《Signal Transduction and Targeted Therapy》2024年第6期2774-2790,共17页Mingjing Yan Junpeng Gao Ming Lan Que Wang Yuan Cao Yuxuan Zheng Yao Yang Wenlin Li Xiaoxue Yu Xiuqing Huang Lin Dou Bing Liu Junmeng Liu Hongqiang Cheng Kunfu Ouyang Kun Xu Shenghui Sun Jin Liu Weiqing Tang Xiyue Zhang Yong Man Liang Sun Jianping Cai Qing He Fuchou Tang Jian Li Tao Shen 
supported by grants from the National Key R&D Program of China(2021YFE0114200,2018YFC2000100);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2021-I2M-1-050);the Project funded by China Postdoctoral Science Foundation(2023M732704);the National Natural Science Foundation of China(81770228,82370584,81470427 and U23A20470);the Beijing Natural Science Foundation(7232141,7212086);the Beijing Hospital Clinical Research 121 Project(121-2016004);the National High Level Hospital Clinical Research Funding(BJ-2021-199,BJ-2023-156,BJ-2019-159).
DEAD-box helicase 17(DDX17)is a typical member of the DEAD-box family with transcriptional cofactor activity.Although DDX17 is abundantly expressed in the myocardium,its role in heart is not fully understood.We genera...
关键词：DDX17 HOMEOSTASIS cardiac 
In silico identification of antiviral compounds for the treatment of chikungunya virus infection:qsar modelling and md simulation analysis
《Medicine in Novel Technology and Devices》2024年第2期102-114,共13页Hayder M Abdulhamza Muthanna S.Farhan Sara.S Hassan Hany Aqeel Al-Hussainy Amjad Ibrahim Oriabi 
supported by the Al-Manara College for Medical Sciences,Department of Pharmacy,Kut University College,Department of Pharmaceutical Chemistry,College of Pharmacy,University of Baghdad,Department of pharmacy,Hilla University College,Dr Hany Akeel institute,Iraqi Medical Research center.
Chikungunya virus(CHIKV),transmitted by arthropods,has gained global recognition for its impact on public health.It has expanded globally,including Africa,Asia,and the Indian subcontinent,and has a helicase protein in...
关键词：Chikungunya virus Machine learning based QSAR Molecular dynamic solution HELICASE 
Long non-coding RNA DPP10-AS1 represses the proliferation and invasiveness of glioblastoma by regulating miR-24-3p/CHD5 signaling pathway被引量：3
《BIOCELL》2023年第12期2721-2733,共13页JIWEI SUN LIANG XU YESEN ZHANG HAORAN LI JIE FENG XUEFENG LU JUN DONG 
supported through the Natural Science Foundation of Jiangsu Province(No.BK20201172);the Key Project of the Jiangsu Health Commission(No.ZDB2020016);the Jiangsu Province Key Research and Development Program:Social Development Project(No.BE2021653).
This investigation aimed to unveil new prospective diagnosis-related biomarkers together with treatment targets against glioblastoma.Methods:The expression levels of long non-coding RNA(lncRNA)DPP10-AS1 were assessed ...
关键词：GLIOBLASTOMA lncRNA DPP10-AS1 miR-24-3p Chromodomain helicase DNA binding protein 5 
Research progress and prospects of nucleic acid isothermal amplification technology被引量：3
《BIOCELL》2023年第11期2385-2395,共11页SHUHUI WU PING XU XIANGBIN XU SONG-BAI LIU 
supported by grants from Jiangsu Higher Education Institution Innovative Research Team for Science and Technology(2021),the Key Technology Program of Suzhou People’s Livelihood Technology Projects(Grant Nos.SKY2021029,SZS2020311);the Open Project of Jiangsu Biobank of Clinical Resources(TC2021B009);the Qing-Lan Project of Jiangsu Province in China(2021,2022).
Nucleic acid(DNA and RNA)detection and quantification methods play vital roles in molecular biology.With the development of molecular biology,isothermal amplification of DNA/RNA,as a new molecular biology technology,c...
关键词：Isothermal amplification Rolling circle amplification Nucleic acid sequence-based amplification Strand displacement amplification Loop-mediated isothermal amplification Helicase-dependent amplification Recombinase polymerase amplification Cross-primer amplification 
Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy被引量：1
《World Journal of Gastrointestinal Surgery》2023年第10期2154-2170,共17页Shuang Yao Yan Yuan Jun Zhang Yang Yu Guang-Hua Luo 
Changzhou Sci and Tech Program,No.CJ20210113;Changzhou Health Young Talents Plan,No.CZQM2021006.
BACKGROUND Our previous study found that the telomerase-associated protein 1(TEP1,rs938886 and rs1713449)and homo sapiens RecQ like helicase 5(RECQL5,rs820196)single nucleotide polymorphisms(SNPs)were associated with ...
关键词：Homo sapiens RecQ like helicase 5 Telomerase-associated protein 1 Polymorphism Peritoneal lavage Heart rate variability Two-dimensional polymerase chain reaction 
Degradation of helicase-like transcription factor(HLTF)byβ-TrCP promotes hepatocarcinogenesis via activation of the p62/mTOR axis被引量：1
《Journal of Molecular Cell Biology》2023年第2期29-42,共14页Ye Tan Di Wu Ze-Yu Liu Hong-Qiang Yu Xiang-Ru Zheng Xiao-Tong Lin Ping Bie Lei-Da Zhang Chuan-Ming Xie 
supported by the Introduction of Special Funds for Talents from the Third Military Medical University(Army Medical University,4174C6)to C.-M.X.
Helicase-like transcription factor (HLTF) has been found to be involved in the maintenance of genome stability and tumoursuppression, but whether its downregulation in cancers is associated with posttranslational regu...
关键词：HLTF β-TrCP MTOR UBIQUITINATION hepatocellular carcinoma cell proliferation metastasis 
DNA/RNA helicase DHX36 is required for late stages of spermatogenesis
《Journal of Molecular Cell Biology》2022年第11期50-61,共12页Kejia Zhang Tianxin Zhang Yujie Zhang Jinyu Yuan Xinzhe Tang Chaobao Zhang Qianqian Yin Yonglian Zhang Ming-Han Tong 
supported by grants from the National Key R&D Program of China(2021YFC2700200 and 2022YFC2702602);the National Natural Science Foundation of China(31930034);the Science and Technology Commission of Shanghai Municipality(19JC1415800 to M.-H.T.).
Spermatogenesis is a highly complex developmental process that typically consists of mitosis, meiosis, and spermiogenesis. DNA/RNA helicase DHX36, a unique guanine-quadruplex (G4) resolvase, plays crucial roles in a v...
关键词：Dhx36 MEIOSIS guanine-quadruplex(G4) Spo11 SYNAPSIS meiotic recombination crossover 
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