Background The Akt2 protein kinase is thought to be a key mediator of the insulin signal transduction process. Akt2 is suggested to play a role in glucose metabolism and the development or maintenance of proper adipos...
supported by the National Key Basic Research and Development Program of China (2006CB503900);National Natural Science Foundation of China (30821065);Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX1-YW-02 and KJCX2-YW-M15); Science and Technology Commission of Shanghai Municipality (07dz05907)
microRNAs are single-stranded,non-coding RNAs that regulate gene expression.The microRNA-16 family has been reported to be involved in cell-cycle regulation,which could also downregulate expression of multiple pro-pro...
Supported by the National Key Basic Research and Development Program of China (Grant No. 2006CB503900);National Natural Science Foundation of China (Grant No. 30821065)
To explore effects of DNA damage on cell-cycle progression in p53-deficient tumor cells, synchronized HeLa cells at G1, S and G2/M phases were treated with methyl methanesulfnate (MMS). The results showed that the MMS...