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国家自然科学基金(51233004): 作品数：15被引量：40H指数：4; 导出分析报告; 相关作者：陈学思马丽莉杨晨光邵俊汤朝晖更多>>; 相关机构：中国科学院中国科学院大学江西师范大学长春工业大学更多>>; 相关期刊：《Chinese Journal of Polymer Science》《高分子学报》《中国科学：化学》《Chinese Journal of Chemistry》更多>>; 相关主题：SCHIFF_BASEPOLYBIODEGRADABILITYACHILLESPOSTOPERATIVE更多>>; 相关领域：理学化学工程医药卫生农业科学更多>>

丙交酯立体选择性聚合研究进展被引量：5: 《中国科学：化学》2020年第7期806-815,共10页周延川张涵段然龙孙志强庞烜陈学思; 国家自然科学基金资助项目(编号:21574124,51503203和51233004)。; 聚乳酸是一类以可再生资源为原料的具有生物可降解性和生物相容性的热塑性材料,已被广泛应用于生物医学、制药和环境等领域.聚乳酸通常是由单体丙交酯开环聚合得到.丙交酯单体有三种旋光异构体,分别为左旋,右旋和内消旋.由于聚合物链段...; 关键词：丙交酯聚乳酸立体选择性开环聚合

Enolic Schiff Base Zinc Amide Complexes： Highly Active Catalysts for Ring-Opening Polymerization of Lactide and ε-Caprolactone被引量：3: 《Chinese Journal of Polymer Science》2018年第10期1123-1128,共6页Chen-Yang Hu Ran-Long Duan Jing-Wei Yang Shu-Jun Dong Zhi-Qiang Sun Xuan Pang Xian-Hong Wang Xue-Si Chen; financially supported by the National Natural Science Foundation of China(Nos.21574124,51503203 and51233004); A series of zinc silylamido complexes based upon NNO tridentate enolic Schiff base framework have been synthesized and characterized. These complexes were tested for the ring opening polymerization of lactide and e-ca...; 关键词：ZINC Β-DIKETONE Ring-opening polymerization LACTIDE Ε-CAPROLACTONE

Recent progress in cationic polymeric gene carriers for cancer therapy被引量：2: 《Science China Chemistry》2017年第3期319-328,共10页Caina Xu Huayu Tian Xuesi Chen; supported by the National Natural Science Foundation of China(51503200,21474104,51233004,51520105004, 51390484);Jilin Province Science and Technology Development Program (20160204032GX);the National Program for Support of Top-notch Young Professionals; In recent years,various carriers for gene delivery nave been developed for biomedical applications.Among all kinds of gene carriers,cationic polymeric carriers for delivery therapeutic gene as non-viral carriers have ...; 关键词：polymeric gene carriers cancer therapy stimuli-responsive carriers multifunctional gene carriers

PDLA-PBS-PDLA三嵌段共聚物的合成及性能被引量：7: 《高等学校化学学报》2015年第11期2329-2334,共6页马丽莉邵俊杨晨光汤朝晖陈学思; 国家自然科学基金(批准号:51273198,51373169,51233004,51303176,51390484,51321062,51403089);国家“八六三”计划项目(批准号:2011AA02A202)资助~~; 合成了末端均为羟基的聚丁二酸丁二醇酯（PBS）预聚物，再以PBS的端羟基引发D-丙交酯（D—LA）开环聚合，得到聚右旋乳酸（PDLA）与PBS的三嵌段共聚物（PDLA—PBS—PDLA）．通过凝胶渗透色谱和核磁共振氢谱进行了结构表征．随着m（D—L...; 关键词：聚丁二酸丁二醇酯右旋聚乳酸 PDLA—PBS—PDLA三嵌段共聚物

Schiff base aluminum catalysts containing morpholinomethyl groups in the ring opening polymerization of rac-lactide: 《Science China Chemistry》2015年第11期1741-1747,共7页Zhijie Guo Ranlong Duan Mingxiao Deng Xuan Pang Chenyang Hu Xuesi Chen; supported by the National Natural Science Foundation of China(51173183,51233004,51390484,51321062,51473029); A series of Schiff base aluminum(III) complexes bearing morpholinomethyl substituents were synthesized. Comprehensive investigations on their stereoselective and kinetic features in the ring opening polymerization of ...; 关键词：POLYLACTIDE morpholinomethyl ring opening polymerization

Gold Nanoparticles for Cancer Theranostics被引量：3: 《Chinese Journal of Chemistry》2015年第9期1001-1010,共10页Hong Liang Huayu Tian Mingxiao Deng Xuesi Chen; This work was financially supported by the National Natural Science Foundation of China （Nos. 51222307, 51233004, 51390484, 21474104 and 51473029）, the Jilin Province Science and Technology Development Program （Nos. 20120306 and 20130521011JH）, and the Open Research Fund of the Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Youth Innovation Promotion Association, CAS.; Gold nanoparticles have seen unprecedented development in the biomedical field, particularly for cancer ther- apy. They have received extensive attention because of their easy preparation, functionalization, biocompat...; 关键词：gold nanoparticles cancer theranostics drug/gene delivery photothermal therapy BIOIMAGING

A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics: 《Science China Chemistry》2015年第7期1159-1168,共10页Zhiming Song Bo Shi Jianxun Ding Xiuli Zhuang Xiaonan Zhang Changfeng Fu Xuesi Chen; financially supported by the National Natural Science Foundation of China(51303174,51473165,51233004,51390484,51273196,51321062,51203153);the Scientific Development Program of Jilin Province(20140520050JH); Complications arising from tendon injury include tendon sheath infection and peritendinous adhesion, in which tendon adhesion often leads to serious motor dysfunction. In this work, the electrospun membranes of poly(L...; 关键词：ANTI-ADHESION Achilles tendon repair BIODEGRADABILITY electrospun membrane poly（L-lactide） poly（ε-caprolactone）

Biomimetic biphasic scaffolds for osteochondral defect repair 5th China-Europe Symposium on Biomaterials in Regenerative Medicine(CESB 2015)Hangzhou,China April 7–10,2015被引量：8: 《Regenerative Biomaterials》2015年第3期221-228,共8页Xuezhou Li Jianxun Ding Jincheng Wang Xiuli Zhuang Xuesi Chen; This work was financially supported by the National Natural Science Foundation of China(Nos.51303174,51273196,51203153,51233004,51390484,and 51321062);the Scientific Development Program of Jilin Province(Nos.20140520050JH and 20140309005GX);the Science and Technology Planning Project of Changchun City(No.14KG045).; The osteochondral defects caused by vigorous trauma or physical disease are difficult to be managed.Tissue engineering provides a possible option to regenerate the damaged osteochondral tissues.For osteochondral recon...; 关键词：biomaterial BIOMIMETIC biphasic scaffold osteochondral regeneration tissue engineering

Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma: 《Chinese Journal of Polymer Science》2015年第5期763-771,共9页Yi-fei Li Hai-yang Yu Hai Sun 刘建国汤朝晖 Dan Wang Lian-you Yu Xue-si Chen; financially supported by the National Natural Science Foundation of China(Nos.51373168,51233004,21104076,51321062 and 51390484);Ministry of Science and Technology of China(International Cooperation and Communication Program 2011DFR51090);the Program of Scientific Development of Jilin Province(Nos.20130206066GX,20130727050YY and 20130521011JH); Herein, cisplatin-loaded poly（L-glutamic acid）-g-methoxy poly（ethylene glycol） nanoparticles were evaluated as a potential chemotherapeutic agent against osteosarcoma by using alone or with an i RGD（internalizing...; 关键词：Nanoparticles Biodegradable polymers Cancer chemotherapy Polymeric drug carrier

Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)被引量：1: 《Chinese Journal of Polymer Science》2015年第4期587-596,共10页Zhi-ming Song Bo Shi 丁建勋 Xiu-li Zhuang Xiao-nan Zhang 付长峰 Xue-si Chen; financially supported by the National Natural Science Foundation of China(Nos.51303174,51321062,51233004,51390484,51273196,and 51203153);the Scientific Development Program of Jilin Province(No.20140520050JH); An electrospun poly（lactide-co-glycolide）（PLGA） membrane was prepared and used to perform the anti-adhesion of Achilles tendon. Throughout the experiments, the membrane showed an appropriate degradation rate, and...; 关键词：ANTI-ADHESION Achilles tendon repair BIODEGRADABILITY Electrospun membrane Poly（lactide-co-glycolide）.

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