云南高校图书馆联盟文献共享服务平台- 国家自然科学基金(81173500)

国家自然科学基金(81173500): 作品数：12被引量：98H指数：7; 导出分析报告; 相关作者：张爱华孙晖李先娜王喜军闫广利更多>>; 相关机构：黑龙江中医药大学更多>>; 相关期刊：《世界科学技术-中医药现代化》《Chinese Herbal Medicines》《Chinese Journal of Natural Medicines》《World Journal of Traditional Chinese Medicine》更多>>; 相关主题：TRADITIONAL_CHINESE_MEDICINE关黄柏中药血清药物化学代谢组学MECHANISMS更多>>; 相关领域：医药卫生更多>>

Chinmedomics:Newer Theory and Application被引量：4: 《Chinese Herbal Medicines》2016年第4期299-307,共9页Xi-jun Wang Ai-hua Zhang Hui Sun Guang-li Yan; Key Program of Natural Science Foundation of State(Grant No.90709019,81430093,81173500,81373930,81302905,81202639);National Key Subject of Drug Innovation(Grant No.2015ZX09101043-005,2015ZX09101043-011); The scientific interpretation of the effectiveness of traditional Chinese medicine（TCM） is a communication channel between Chinese medicine and modern medicine. The evaluation of TCM efficacy is an important prerequ...; 关键词：active constituents biomarkers Chinmedomics effectiveness traditional Chinese medicine

基于细胞代谢组学技术的关黄柏潜在有效成分木兰碱对前列腺癌细胞的治疗作用研究被引量：8: 《世界科学技术-中医药现代化》2016年第10期1740-1748,共9页张天雷邱时李先娜张爱华孙晖; 国家自然科学基金委面上项目(81173500):基于知柏地黄丸配伍环境的关黄柏治疗肾阴虚相火亢盛的药效物质基础研究;负责人:孙晖; 目的:本文在木兰碱药效学研究基础之上,进行基于UPLC-HDMS/MS技术的细胞代谢组学研究,探讨木兰碱抗前列腺癌的潜在作用机制。方法:将对数期22RV1前列腺癌细胞以适宜密度接种并分为空白组及木兰碱给药组,以细胞形态学观察、MTT比色法以...; 关键词：木兰碱前列腺癌代谢组学生物标志物

利用血液代谢组学研究关黄柏生物碱对慢性非细菌性前列腺炎模型大鼠的干预作用被引量：15: 《世界科学技术-中医药现代化》2016年第10期1709-1719,共11页孙晖李先娜张颖李瑞芳岳姝崎张爱华王喜军; 国家自然科学基金委重点项目(81430093):中药体内药效物质基础的系统分析方法学--中医方证代谢组学研究;负责人:王喜军;科学技术部"重大新药创制"国家科技重大专项(2015ZX09101043-011):中药经典名方整合作用机制关键技术研究;负责人:王喜军;国家自然科学基金面上项目(81173500):基于知柏地黄丸配伍环境的关黄柏治疗肾阴虚相火亢盛的药效物质基础研究;负责人:孙晖; 目的:本研究应用行为学、组织病理学和代谢组学技术研究关黄柏生物碱对慢性非细菌性前列腺炎(Chronic Nonbacterial Prostatitis,CNP)的干预作用,从血液代谢组学角度阐释关黄柏生物碱对CNP模型大鼠体内代谢水平的影响及其作用机制。方法...; 关键词：关黄柏生物碱代谢组学慢性非细菌性前列腺炎

基于体内过程的关黄柏在知柏地黄丸等类方配伍环境下血中移行成分分析被引量：8: 《世界科学技术-中医药现代化》2016年第10期1730-1739,共10页李先娜邹迪李冰冰闫广利王美佳刘志东张爱华孙晖; 国家自然科学基金委面上项目(81173500):基于知柏地黄丸配伍环境的关黄柏治疗肾阴虚相火亢盛的药效物质基础研究;负责人:孙晖; 目的:本研究主要探讨了关黄柏在特定配伍环境下血中移行成分与功效取向的相关性。方法:研究应用UPLC-HD-MS/MS联用技术建立关黄柏及知柏地黄丸等类方口服给药后大鼠血中移行成分分析方法。采用主成分分析(PCA)及正交偏最小二乘判别分析(...; 关键词：关黄柏清热燥湿退虚热血中移行成分药效物质基础中药血清药物化学

Novel chinmedomics strategy for discovering effective constituents from ShenQiWan acting on ShenYangXu syndrome被引量：15: 《Chinese Journal of Natural Medicines》2016年第8期561-581,共21页ZHOU Xiao-Hang ZHANG Ai-Hua WANG Liang TAN Yun-Long GUAN Yu HAN Ying SUN Hui WANG Xi-Jun; supported by the Key Program of Natural Science Foundation of State(Nos.81430093,81173500,81373930,81302905,81202639);National Key Subject of Drug Innovation(Nos.2015ZX09101043-005,2015ZX09101043-011);the Natural Science Foundation of Heilongjiang Province of China(H2015038);Youth Innovative Talent Program of Heilongjiang Province of China(UNPYSCT-2015118); Elucidation of the efficacy of traditional Chinese medicine(TCM) is of importance for scientists of modern medicine to understand the value of TCM clinical experience, and it is necessary to have a biological language...; 关键词：Chinmedomics ShenQiWan ShenYangXu syndrome Metabolomics Serum pharmacochemistry

Pharmacokinetics Applications of Traditional Chinese Medicines: 《World Journal of Traditional Chinese Medicine》2016年第1期42-47,共6页Qiu-Ju Li Ai-Hua Zhang Hui Sun Xi-Jun Wang; supported by grants from the Key Program of Natural Science Foundation of State(Grant No.81430093,90709019,81373930,81173500,81302905,81202639);Natural Science Foundation of Heilongjiang Province of China(H2015038); Traditional Chinese medicine(TCM) has been widely used in many oriental countries for thousands of years and played an indispensable role in the prevention and treatment of diseases, especially the complicated and chr...; 关键词：Traditional Chinese medicine PHARMACOKINETICS Drug discovery Active constituents

Metabolomics and Its Potential in Drug Discovery and Development From TCM被引量：3: 《World Journal of Traditional Chinese Medicine》2015年第4期26-32,共7页Hang Chu Ai-Hua Zhang Ying Han Xi-Jun Wang; supported by grants from the Key Program of Natural Science Foundation of State(Grant No.81430093,90709019,81373930,81173500,81302905,81202639);Natural Science Foundation of Heilongjiang Province of China(H2015038); Metabolomics, an omic science in systems biology, is the comprehensive profiling of metabolic changes occurring in living systems and has been widely used in the modern research of traditional Chinese medicine(TCM). T...; 关键词：Metabolomics traditional Chinese medicine FORMULAE BIOMARKER drug discovery

UPLC-Q-TOF/MS-based metabolomic studies on the toxicity mechanisms of traditional Chinese medicine Chuanwu and the detoxification mechanisms of Gancao, Baishao, and Ganjiang被引量：23: 《Chinese Journal of Natural Medicines》2015年第9期687-698,共12页DONG Hui YAN Guang-Li HAN Ying SUN Hui ZHANG Ai-Hua LI Xian-Na WANG Xi-Jun; supported by the Key Program of National Natural Science Foundation of China(Nos.81430093,81173500,81373930,81302905,81102556,and 81202639);National Key Subject of Drug Innovation(Nos.2015ZX09101043-005 and 2015ZX09101043-011);Heilongjiang University of Chinese Medicine Scientific Research Fund Projects(No.201307);Application Technology and Development of Youth Talents Project of Harbin,China(2014RFQXJ116); Chuanwu(CW), a famous traditional Chinese medicine(TCM) from the mother roots of Aconitum carmichaelii Debx..(Ranunculaceae), has been used for the treatment of various diseases. Unfortunately, its toxicity is frequen...; 关键词：Metabolomics Aconitum Chuanwu Detoxification Compatibility

Metabolomics Analysis of Health Functions of Physalis Pubescens L. using by Ultra-performance Liquid Chromatography/Electrospray Ionization Quadruple Time-of-Flight Mass Spectrometry被引量：2: 《World Journal of Traditional Chinese Medicine》2015年第3期9-20,共12页Hang Chu Hui Sun Guang-Li Yan Ai-Hua Zhang Chang Liu Hui Dong Xiang-Cai Meng Xi-Jun Wang; supported by grants from the Key Program of Natural Science Foundation of State (Grant No.81430093, 90709019, 81373930, 81173500, 81302905, 81202639);National Key Technology Research and Development Program of the Ministry of Science and Technology of China (Grant No.2011BAI03B03, 2011BAI03B06, 2011BAI03B08);Natural Science Foundation of Heilongjiang Province of China(H2015038);Specialized Research Fund for the Doctoral Program of Higher Education (Grant No.20122327120006);Fund Project of Heilongjiang Provincial Department of Education (Grant No.12521498); Herbal medicines may benefit from metabolomics studies, and applying metabolomics may provide answers about which herbal interventions may be effective for individuals, which metabolic processes are triggered, and the...; 关键词：Metabolomics Physalis pubescens L ANTIOXIDANT ANTI-FATIGUE metabolic pathway biomarkers

Natural alkaloids: basic aspects, biological roles, and future perspectives被引量：13: 《Chinese Journal of Natural Medicines》2014年第6期401-406,共6页QIU Shi SUN Hui ZHANG Ai-Hua XU Hong-Ying YAN Guang-Li HAN Ying WANG Xi-Jun; supported by the grants from the Key Program of Natural Science Foundation of State(Nos.90709019,81173500,81373930,81302905,81102556,81202639);the National Key Technology Research and Development Program of the Ministry of Science and Technology of China(Nos.2011BAI03B03,2011BAI03B06,2011BAI03B08);the National Key Subject of Drug Innovation(No.2009ZX09502-005); Natural products have gained popularity worldwide for promoting healthcare, as well as disease prevention. Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloid...; 关键词：Natural product ALKALOIDS Biological roles Health benefits

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