国家重点基础研究发展计划(2012AA022501)

作品数：6被引量：1H指数：1
导出分析报告
相关作者：王超更多>>
相关机构：北京大学更多>>
相关期刊：《Chinese Journal of Chemistry》《Science China Chemistry》《Journal of Chinese Pharmaceutical Sciences》《Chinese Chemical Letters》更多>>
相关主题：SIRNATERMINALCONJUGATEPEPTIDECONJUGATES更多>>
相关领域：医药卫生生物学理学自动化与计算机技术更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-6
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Transfection of 3′,3′′-bis-peptide-siRNA conjugate by cationic lipoplexes mixed with a neutral cytosin-1-yl-lipid
《Journal of Chinese Pharmaceutical Sciences》2017年第10期719-726,共8页杨梦依 孙晶 王超 张艳芬 张礼和 杨振军 
The National Natural Science Foundation of China(Grant No.21778006 and 20932001);the Ministry of Science and Technology of China(Grant No.2012AA022501)
Cationic lipids have been applied to siRNA delivery for tumor therapeutics. However, the excess positive charges of these nanoplexes may lead to high cytotoxicity and nonnegligible immunogenicity both in vitro and in ...
关键词：3＇ 3＂-Bis-peptide siRNA conjugate Gemini-like cationic lipid Cytosin-1-yl-lipid Melanoma therapy 
Evaluation of the intracellular trafficking of siRNAs in A375 cells by confocal laser scanning microscopy
《Journal of Chinese Pharmaceutical Sciences》2016年第12期859-868,共10页Yiping Diao Jing Sun Mengyi Yang Bo Xu Lihe Zhang Zhenjun Yang 
Ministry of Science and Technology of China(Grant No.2012AA022501,2012CB720604);the National Natural Science Foundation of China(Grant No.20932001,81302626)
Investigation intracellular trafficking of siRNAs following their delivery to cells is of great interest to elucidate dynamics of siRNA in cytoplasm. In this study, we present a novel confocal laser scanning microsco...
关键词：siRNA/CLD complex Endosomal escape Cytoplasmic distribution Confocal laser scanning microscopy 
Loss of silencing activity caused by 5′-terminal modification with D-/L-isonucleotide(isoNA) or locked nucleic acid(LNA) could not be restored by 5′-terminal phosphorylation被引量：1
《Science China Chemistry》2014年第2期329-334,共6页HUANG Ye CHEN Zhuo WANG Zhuo LI YaTing CHEN Yue YANG ZhenJun ZHANG LiHe 
supported by the National Natural Sciences Foundation of China(20932001);the Program of the Ministry of Science and Technology of China(2009ZX09503,2012AA022501,2012CB720604)
In this study,a series of 5′-phosphorylated siRNAs with D-/L-isonucleotide(isoNA)or locked nucleic acid(LNA)incorporated at the 5′-terminus were synthesized.It was found that after incorporating either isoNA or LNA ...
关键词：isonucleotide locked nucleic acid （LNA） 5＇-terminal phosphorylation 
Multiresponsive Polymer Assemblies Achieved by a Subtle Chain Terminal Modification
《Chinese Journal of Chemistry》2014年第1期51-56,共6页Weiwei Liu Yucai Wang Yang Li Feng Wang Xianzhu Yang Tianmeng Sun Jinzhi Du Jun Wang 
This work was supported by the Ministry of Science and Technology of China (Nos.2010CB934001,2012AA022501,2013CB933900),the National Natural Science Foundation of China (Nos.51203145,51125012),the Fundamental Research Funds for the Central Universities (No.WK2070000008) and the Open Project of State Key Laboratory of Supramolecular Structure and Materials (No.SKLSSM201301).
Inspired by the influence of chemical structure of end groups on the phase transition temperature of thermoresponsive polymers,we demonstrated a strategy to control the multi-responsiveness of polymer assemblies via s...
关键词：multi-responsive THERMORESPONSIVE PHASE-TRANSITION POLYPHOSPHOESTER 
Synthesis and biological evaluation of peptide-siRNA conjugates with phosphodiester unit as linker
《Science China Chemistry》2013年第11期1542-1549,共8页WANG XiaoFeng HUANG Ye LIU Yang CHEN Yue JIN HongWei ZHENG Yi DU Quan YANG ZhenJun ZHANG LiHe 
supported by the National Natural Science Foundation of China(20932001);the Ministry of Science and Technology of China(2012AA022501);the National Key Basic Research Program of China(2012CB720604)
In this paper,a series of peptide-siRNA conjugates with phosphodiester unit as the linker targeting to Cdc2 gene were synthesized by solid phase stepwise strategy.The conjugation of peptides at either 3’-terminus of ...
关键词：SIRNA PEPTIDE conjugate solid synthesis 
Solid phase synthesis of peptide–siRNA conjugates containing disulfde bond unit
《Chinese Chemical Letters》2013年第10期873-876,共4页Xiao-Feng Wang Xian-Tao Yang Yue Chen Yang Liu Lang Zou Zhen-Jun Yang Li-He Zhang 
supported by the National Natural Science Foundation of China(No.20932001);the Ministry of Science and Technology of China(Nos.2012CB720604,2012AA022501)
A disulfide-modified nucleoside was designed and synthesized. After loading the modified nucleoside on controlled pore glass （CPG）, solid phase synthesis strategy was used to prepare peptide-oligonucleotide conjugat...
关键词：siRNA Solid synthesis Disulfide bond Peptide Conjugate 
全选清除导出
共1页<1>
检索报告 对象比较 聚类工具 使用帮助 返回顶部